摘要
目的探讨儿童传染性单核细胞增多症(IM)的临床特点与发病年龄的关系。方法 312例IM儿童分成0～3岁、～6岁、～15岁3组,进行回顾性分析。结果 IM儿童中6岁以下占74.4%,春季和秋季高发。0～3岁组发热天数平均(7.08±3.31)d,～6岁组平均(7.91±3.78)d,～15岁组平均(12.38±4.14)d,～15岁组与其他组差异有统计学意义(P<0.01)。各年龄组咽峡炎(100%)、淋巴结肿大(82.69%)、肝肿大(66.7%)、脾肿大(62.5%)、鼻塞(42.3%)组之间差异无统计学意义(P>0.05);眼睑浮肿(36.2%)～15岁组明显低于其他组(P<0.05),皮疹(23.1%)在0～3岁组多见(P<0.05)。外周血白细胞年幼儿升高明显,异型淋巴细胞年幼儿偏低,血清ALT、AST在年长儿偏高,血清LDH在各年龄组均呈高值,血清嗜异凝集试验年长儿阳性率高。结论儿童IM某些临床特点与发病年龄有关,应予以重视,以提高确诊率。
Objective To explore the clinical features of childhood infectious mononucleosis （IM） in relation to the age of the children. Methods The clinical features of IM were retrospectively analyzed in 312 children with IM, who were divided into three age groups, and consisting of the 0 - 3 years old group, the 3 - 6 years old group and the 6 - 15 years old group, respectively. Results Most IM （74.4%） occurred in children under 6 years old, and usually with a high incidence in spring and autumn. The major clinical presentations in IM children were fever, angina, enlarged lymphnodes and hepatosplenomegaly. Duration of fever was longer in the older age group. The eruption and eyelids edema were more often detected in the younger age group. The leukocyte count was higher and the atypieal lymphocyte （AL） was lower in the younger age group. The positive rate of Paul-Bunnell test was higher in the older age group. The serum levels of alanine amino transferase （ALT）, aspartate aminotransferase （AST） and lactate dehydrogenase （LDH） were high in all age group. Conclusions The clinical features of childhood IM are associated with the age, which needs to be taken into consideration in order to improve the diagnosis of IM.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2011年第6期518-521,共4页
Journal of Clinical Pediatrics
