摘要
目的观察陕西省慢型、潜在型克山病患者的临床特点和心肌损伤标志物血液水平,探讨克山病发生和发展的机制。方法选择慢型、潜在型克山病患者70例,分别进行心电图、X线胸片、超声心动图等检查,并采集克山病患者和病区健康人静脉血,分别检测血浆脑利钠肽(BNP)、血清肌钙蛋白I(cTnI)含量。结果 (1)25例慢型克山病患者X线片显示100%都有心脏增大,且以重度增大多见;心电图异常改变,且往往几种异常同时并存;心脏超声心动图示心功能明显降低。45例潜在型克山病患者心脏轻度增大者多见,而且心电图往往只有一项改变。(2)克山病患者BNP水平明显高于病区健康人,差异有统计学意义(P<0.01),且慢型克山病患者高于潜在型克山病患者;cTnI在慢型、潜在型克山病患者中均无明显改变。结论克山病仍然是一个严重地方性公共卫生问题,X线片检查、心电图检查、超声心动图检查为克山病诊断的主要手段,BNP和cTnI联合检测对于克山病患者心脏状况和功能判断有很好的临床价值。
Objective To observe the clinical characteristics and analysis the level of myocardial injury markers in blood of Keshan disease（KSD）patients in Shanxi province,and to study mechanism in the development of Keshan disease. Methods 70 KSD patients enrolled and underwent ECG,chest X-ray,echocardiography and other tests,Th~ plasma contents of BNP and cTnI of KSD patients and healthy subjects in KSD epidemic regions were tested. Results （1）25 patients with chronic Keshan disease were 100% cardiac enlargement on chest X-ray,and most were heavy; ECGs were abnormal and often coexist with several types;cardiac ultrasound showed significantly decrease of cardiac function. Mild cardiac enlargement was more common in 45 patients with potential Keshan disease, but often on13 one item changed in ECGs. （2） BNP level of patients with Keshan disease was significantly higher than that oJ healthy subjects in the same endemic regions（P〈0.01） ,and which in chronic KSD patients was significantly highe~ than that in the potential KSD patients;The result of cTnI level was not significantly different between chronic KSE patients and potential ones. Conclusion Keshan disease remains a serious problem in public health. X-ray examination,ECG,echocardiography are the primary methods for the diagnosis of Keshan disease,and BNP combined with cTnI offer a good clinical value for both the detection of Keshan disease and evaluate cardiac functions of patient with Keshan disease.
出处
《检验医学与临床》
CAS
2011年第10期1187-1188,1190,共3页
Laboratory Medicine and Clinic
