摘要
目的:观察补肾化痰方对去卵巢骨质疏松症大鼠血清脂联素抗酒石酸酸性磷酸酶5b(tartarte-resistant acid phosphatase 5b,TRACP5b)和血清β-I型胶原C-末端肽(C-terminal telopeptides of type I collagen,β-CTX)水平的影响。方法:SD大鼠行双侧卵巢切除术;术后3月以中剂量和高剂量补肾化痰方灌胃给药;术后5月,双能X线骨密度测定仪检测大鼠股骨骨密度,ELISA法检测大鼠血清TRACP5b和β-CTX含量。结果:补肾化痰方中、高剂量组均能显著提高去卵巢骨质疏松症大鼠的骨密度,降低血清TRACP5b和β-CTX水平。结论:补肾化痰方对去卵巢大鼠骨质疏松症有较好的治疗作用。
Objective：To observe the influence of Tonifying the Kidney and Eliminating the Phlegm Prescription on serum TRACP5b andβ-CTX in ovariectomized rats.Methods：Female SD rats were performed the ovariectomy operation.Drug treatment was given to the rats three months after the operation.Two months after being fed with the large dose and the middle dose of Tonifying the Kidney and Eliminating the Phlegm Prescription respectively,the bone mineral density（BMD） of the rats was measured by dual energy X-ray absorptionmetry.The levels of serum TRACP5b and β-CTX were tested with ELISA.Results：Tonifying the Kidney and Eliminating the Phlegm Prescription can decrease the measuring deviation of TRACP5b and β-CTX,but increase the bone density.Conclusion：Tonifying the Kidney and Eliminating the Phlegm Prescription can effectively prevent osteoporosis in female rats induced by ovariectomy.
出处
《现代生物医学进展》
CAS
2011年第12期2227-2229,共3页
Progress in Modern Biomedicine
基金
湖北省自然科学基金资助项目(2007ABA237)
关键词
补肾化痰方
骨质疏松症
TRACP5B
β-CTX
Tonifying the Kidney and Eliminating the Phlegm Prescription
Osteoporosis
TRACP5b
β-CTX
