摘要
目的研究关节内注射玻璃酸钠后埘老年膝骨关节炎患者膝关节木体感觉的影响。方法共53例老年患者人选该研究。受试者被随机分为治疗组（35例）和安慰剂组（18例）。治疗组患者行双侧膝关节玻璃酸钠（阿尔治）关节内注射，安慰剂组则予双侧膝关节注射生理盐水。测量膝关节本体感觉，西方安大略和麦克马斯特大学（WOMAC）骨关节炎指数评分表用于评估膝关节疼痛和功能改善情况。结果共50例患者100个膝关。市进行r评估，平均绝对角误差值在第4次注射岳1周，治疗组明显低于安慰剂组，分别为（1．8±0．9）分和（2．9±1．1）分（t=2．42，P=0．02）；治疗组WOMAC积分在注射玻璃酸钠1周后开始明显下降，治疗组和安慰剂组WOMAC积分分别为（8．7±3．1）分和（11．5±4．0）分（t=0．73，P〈0．05）。结论老年膝骨关节炎患者关节内注射玻璃酸钠可短时间改善膝关节本体感觉及疼痛。
Objective To investigate the short term effects of intra-articular injection of hyaluronan on proprioception of the knee in gerontal patients with osteoarthritis （OA）. Methods The 53 gerontal patients were included in this study. The study included treatment group （n=35） and the placebo group （n=18）. Hyaluronan was intra-articularly injected into both knees of the subjects in treatment group, whereas physiological saline was intra-articularly injected in the placebo group. Proprioception test was performed, and Western （）ntario and McMaster Universities（WOMAC） scales were used to evaluate pain and physical function. Results Statistical analysis was performed on 100 knees of 50 patients who completed the trial. Compared with the placebo group,the average absolute angular error （AAAE） value in the treatment group was detected to be statistically lower one week after the 4th injection （1.8±0.9 vs. 2.9±1.1,t=2.42,P 0.02）,and WOMAC was lower in the treatment group after one week （8.7 ±3.1 vs. 11.5±4. 0, t=0. 73, P〈0.05）. Conclusions Intra articular injection of hyaluronan in gerontal patients with knee OA leads to a short term increase in proprioeeption, and significant improvement in the functional conditions of patients.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2011年第6期488-490,共3页
Chinese Journal of Geriatrics
关键词
骨关节炎
膝
本体感觉
Osteoarthritis, knee
Proprioception
