摘要
目的:探讨躁狂发作患者血清细胞因子白细胞介素1(IL-1β)与C-反应蛋白(CRP)在发病中的作用。方法:躁狂发作患者20例(躁狂发作组),正常对照组20例。采用酶联免疫吸附法(ELISA)测定血清IL-1β的水平,采用散射比浊法测定血清CRP水平;并以Bech-Rafaelsen躁狂量表(BRMS)进行评定。结果:躁狂发作组血清IL-1β(8.90±5.63)pg/L和CRP(6.28±5.48)mg/L水平显著高于正常对照组血清IL-1β(3.31±3.27)pg/L和CRP(2.50±1.44)mg/L水平。相关分析发现,躁狂发作组血清IL-1β水平与患者目前年龄有显著的正相关(r=0.375,P<0.05)。结论:血清IL-1β和CRP水平升高可能是躁狂发作的免疫学标志之一;躁狂发作者细胞因子IL-1β和CRP表达异常可能与躁狂发作的发病机制有关。
Objective： By means of measuring the level of serum cytokine interleukin-1 （ IL-1β） and C- reactive protein（CRP） in patients with mania, to explore the role in mania. Method：There were 20 patients with mania, and 20 healthy controls in our study. To measure the level of serum IL-1β in patients with mania and healthy controls by enzymatic-linked immunosorbent assay （ELISA）, and serum CRP concentrations by scatter rate nephelometry, Bech-Rafaelsen mania scale （BRMS） was also used to evaluate. Results：There was signif- icant higher in the level of serum IL-1β（ 8.90 ± 5.63 ） pg/L, CRP （6.28 ± 5.48 ） mg/L in patients with mania than controls IL-1β （3.31 ±3.27 ） pg/L, CRP （2.50 ± 1.44） mg/L. There was significant positive correlation in the serum IL-1β level and disease onset years （ r = 0. 375, P 〈 0.05 ）. Conclusion： The increases in the level of serum IL-1βCRP in patients with mania may be immunological markers of mania; the abnormality of cytokine IL-1β and CRP level suggests they are possible related with the pathophysiology of mania.
出处
《临床精神医学杂志》
2011年第3期187-188,共2页
Journal of Clinical Psychiatry
