摘要
目的:了解首发精神分裂症患者认知功能损害特点以及治疗对认知功能的影响。方法:对37例符合中国精神障碍分类与诊断标准第3版首发精神分裂症诊断标准的患者于治疗前及治疗8周后采用华文认知能力量表(CCAS)、阳性与阴性症状量表(PANSS)进行评定;同时调查患者的临床特征。结果:精神分裂症患者治疗后CCAS工作记忆(t=3.315,P<0.01)、学习能力(t=4.726,P<0.01)、推理能力(t=4.209,P<0.01)、加工速度(t=6.253,P<0.01)、空间/计算(t=5.111,P<0.01)等认知功能和言语智商(t=3.769,P<0.01)、操作智商(t=3.552,P<0.01)以及总智商(t=3.972,P<0.01)均较治疗前有不同程度提高;治疗前后比较差异均有统计学意义。经Pearson相关分析,治疗前后总智商的差值与PANSS总分及阳性总分差值具有相关性(r分别=0.564、0.756,P<0.05)。结论:首发精神分裂症患者在发病初期就存在认知功能损害;奥氮平等药对精神分裂症的认知损害具有一定改善作用,短时记忆某些成份的改善与精神症状(阳性症状)的好转具有相关性。
Objective： To explore the characteristics of cognition function impairment and the treatment influence on cognitive function in patients with first-episode schizophrenia. Method：37 first-episode schizophrenic patients meeting with Chinese classification of mental disorders-3nd version were evaluated with Chinese cognitive ability scale （CCAS） and positive and negative syndrome scale （PANSS） before treatment and after 8 weeks treatment. Meanwhile the clinical features were investigated in these patients. Results：There were significant improvement in cognitive function in CCAS such as working memory （ t = 3.315, P 〈 0. 01 ） , study capability （ t =4. 726 ,P 〈0.01 ） ,reasoning capability （ t =4. 209 ,P 〈0.01 ） ,process speed （ t =6. 253 ,P 〈0. 01 ） and space or calculation （ t = 5. 111, P 〈 0.01 ） ; and in language intelligence quotient （ t = 3. 769, P 〈 0.01 ）, performance intelligence quotient （ t = 3. 552 ,P 〈 0. 01 ） and general intelligence quotient after treatment （ t = 3. 972 ,P 〈 0.01 ） , compared with those before the treatment. The changes in general intelligence quotient between before and after treatment were significantly correlated with the total PANSS score and the changes of the total PANSS positive syndrome score （ r = 0. 564, and r = 0. 756, P 〈 0. 05 ） by Pearson correlated analysis. Conclusion：First-episode schizophrenia have impairment in cognitive function in their early onset stage. Olanzapine can improve the cognitive function to some degree with some short memory improved related to the improvement in positive psychotic symptoms.
出处
《临床精神医学杂志》
2011年第3期156-158,共3页
Journal of Clinical Psychiatry
基金
江苏省卫生厅重大课题资助项目(K200413)
关键词
精神分裂症
认知功能
华文认知能力量表
schizophrenia
cognitive function
Chinese cognitive ability scale
