摘要
目的检测白癜风患者血清中15种神经内分泌免疫因子（ANG-Ⅱ、EP-β、IFN-γ、sICAM-1、5-HT、IL-10、酪氨酸酶抗体IgM、TNF-α、IL-8、IL-6、酪氨酸酶抗体IgG、IL-2、NE、Coaisol、E），并结合维吾尔医理论探讨其与白癜风发病的关系。方法采用EHSA测定175例白癜风患者血清中上述指标水平，并与60例正常人对照组比较。结果175例白癜风患者血清ANG-Ⅱ、EP—B、IFN-γ、sICAM—1、5-HT、IL-10、酪氨酸酶抗体IgG、NE、Cortisd、E的浓度显著性高于对照组，差异有统计学意义（P〈0．01）。而TNF-α、IL-8、IL-2、IL-6浓度低于对照组，差异有统计学意义（P〈0．01）。IgM浓度与对照组差异无统计学意义（P〉0．05）。稳定期患者ANG-Ⅱ、5-HT、IL-8、Cortisd浓度高于进展期患者，差异有统计学意义（P〈0．01）。其余指标差异无统计学意义。结论白癜风发病过程是一个神经内分泌免疫网络的综合过程，与维吾尔医“kuwiti taliiy”（自然力）失调致白癜风理论是否一致值得研究。
Objective To measure the serum levels of 15 neuroendocrine and immune factors, including angiotensin-Ⅱ （ANG-Ⅱ ）, endorphin-β （EP-β）, interferon-γ （IFN-γ）, soluble intercellular adhesion molecule-1 （slCAM-1）, 5-thrombotonin （5-HT）, interleukin-10 （IL-10）, lgM, tumor necrosis-or （TNF-α）, IL-8, IL-6, IgG, IL-2, norepinephrine, cortisol and adrenaline in patients with vitiligo, and to analyze their association with the development of vitiligo according to traditional Uyghur medicine theory. Methods Enzyme-linked immunosorbent assay （ELISA） was conducted to measure the serum levels of the above 15 neuroendoerine and immune factors in 175 patients with vitiligo and 60 normal human controls. Results There was a signitleant increase in the serum levels of ANG-Ⅱ , EP-13, IFN-γ slCAM-1, 5-HT, IL-10, IgG, norepinephrine, eortisol and adrenaline, together with a decrease in those of TNF-α, IL-8, IL-2 and IL-6 in patients with vitiligo compared with the controls （all P 〈 0.01 ）. No statistical difference was observed for the serum level of IgM between the patients and controls （P 〉 0.05）. Increased serum levels of ANG-11,5-HT, IL-8 and eortisol were noted in patients with stable vitiligo in comparison with those with progressive vitiligo （all P 〈 0.01 ）; while the levels of the other factors were similar between the stable and progressive vitiligo patients. Conclusions The development of vitilito is a comprehensive process with the involvement of various neuroendocrine and immune factors, and whether the conclusion agrees with the traditional Uyghur medicine theory that imbalaneed ＂kuwiti tabiiy＂ [＂Nature oower＂ （of human body） ] induces vitiligo derserves further studies.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
2011年第6期390-392,共3页
Chinese Journal of Dermatology
基金
基金项目：“十一五”国家科技支撑计划课题（2007BA148805）
国家自然科学基金地区科学基金（81060315）
关键词
白癜风
免疫因子类
医学
维吾尔族
Vitiligo
Immunologic factors
Medicine, Uygur nationality
