摘要
为了观察易瑞沙治疗晚期肺腺癌的疗效及毒副反应,对化疗后复发或不能耐受化疗或不愿接受化疗的41例晚期肺腺癌患者,口服易瑞沙治疗,250 mg/d,4周后开始评价疗效。结果显示,41例患者均可评价疗效,CR 1例,PR 16例,SD 13例,PD 11例,总有效率为41.5%,疾病控制率为73.2%。对于女性、不吸烟者受益更好。最常见不良反应为轻度腹泻、痤疮样皮疹。初步研究结果提示,易瑞沙治疗晚期肺腺癌安全有效,毒副反应轻。
The objective of this study was to observe herapeutic effect and toxic reaction of advanced pulmonaryadenocarcinoma treated with Iressa.And 41 cases of patients of advanced pulmonaryadenocarcinoma who were recurrence of postchemotherapy,not tolerant to chemotherapy,or reluctancy to accept chemotherapy,they were treated with Iressa taken orally 250 mg/d,Evaluation of therapeutic effect was carried out after treatment starting.All 41 cases of patients were measurable,among which complete response was 1 case,partial response 16 cases,stable disease 13 cases,progressive disease 11 cases,disease control rate（DCR） 73.2 percent,and total effective rate was 41.5 percent.Women and non-smokers could profit from this treatment.The most common side effect were slight diarrhoea andacneform eruptions.It is safe and effective to treat advanced pulmonary adenocarcinoma with Iressa,and side effect is tolerable.
出处
《中华肿瘤防治杂志》
CAS
2011年第4期306-308,共3页
Chinese Journal of Cancer Prevention and Treatment
关键词
肺肿瘤/药物疗法
腺癌
易瑞沙/投药和剂量
lung neoplasms/drug therapy
adeno carcinoma
iressa/administration and dosage
