摘要
目的探讨影响老年胃癌患者预后的因素。方法分析我院2005—2009年收治的238例接受手术治疗的老年(≥60岁)胃癌患者,对性别、年龄、民族、合并症、肿瘤部位、Borrman分型、细胞的分化程度、手术方式、术后辅助治疗、肿瘤的浸润深度、临床分期、远处转移、肿瘤标记物癌胚抗原(CEA)水平等因素与预后的关系进行统计学分析,以Kaplan-Meier方法进行生存率分析,Log-rank检验进行单因素分析,运用COX回归模型进行多因素分析以评价影响老年胃癌患者生存的独立影响因素。结果 238例患者1年累计生存率为72.6%、3年累计生存率为25.4%、5年累计生存率为5.8%。单因素分析结果显示,民族、肿瘤浸润深度、远处转移、临床分期、手术方式、术后辅助治疗、CEA水平是患者预后的影响因素(P<0.01);COX多因素回归分析结果显示,民族、肿瘤浸润深度、临床分期、术后是否接受放化疗是影响老年胃癌患者预后的独立因素。结论民族、肿瘤浸润深度、肿瘤分期、术后辅助治疗是老年胃癌患者预后的独立影响因素。
Objective To indentify the prognostic factors of gastric cancer in elder patients.Methods A total of 238 cases of aged gastric cancer patients treated by our hospital from 2005 to 2008 were retrospectively reviewed.Associations of prognosis with factors including age,sex,race,complications,tumor position,Borrman type,differentiation status,operative technique,adjunctive therapy,carcino-embryonic antigen（CEA） levels and so on were analyzed.Survival rates were analyzed with Kaplan-Meier method.Univariate and multivariate analysis were taken out using Log-rank test and COX regression model.Results Of the 238 patients,1-year,3-year,and 5-year survival rates were 72.6%,25.4%,and 5.8% respectively.On univariate analysis,significant prognostic factors were race,tumor infiltration depth,distant metastasis,operative technique,postoperative adjuvant therapy,CEA levels and clinical stageing were among the factors significantly affecting prognosis（P0.01）.On multivariate analysis,independent prognostic factors include race,tumor infiltration depth,postoperative adjuvant therapy and clinical staging（P0.05）.Conclusion Race,tumor infiltration depth,postoperative adjuvant therapy and clinical staging are independent prognostic indicators of survival in elder patients with gastric cancer.
出处
《中国全科医学》
CAS
CSCD
北大核心
2011年第18期2010-2013,共4页
Chinese General Practice
关键词
老年人
胃肿瘤
预后
危险因素
新疆
Aged
Stomach neoplasms
Prognosis
Risk factors
Xinjiang
