摘要
目的探讨及早应用阿托伐他汀与溶栓治疗急性ST段抬高心肌梗死(STEM I)的疗效与安全性及对心血管事件的影响。方法选取2008年11月—2009年9月住院治疗行急诊溶栓成功的72例患者。治疗组(37例)在常规治疗的基础上,24h内加服阿托伐他汀80mg,1次/晚,用药12个月;对照组(35例)按急性STEM I常规溶栓、抗栓、抗缺血等治疗。观察两组患者治疗4个月和随访1年的临床情况,包括血脂、超敏C反应蛋白(hs-CRP)、心血管事件发生率、不良反应和并发症。结果用药治疗4个月,治疗组血脂、hs-CRP变化明显优于对照组;随访1年间治疗组心血管事件发生率明显低于对照组,且无严重不良反应发生。结论及早应用大剂量阿托伐他汀与溶栓治疗急性ST段抬高心肌梗死,能减少心血管事件发生率,改善临床预后;且用药较安全、不良反应少,未增加溶栓后的并发症。
Objective Explore the early application atorvastatin and thrombolytic therapy acute st-elevation myocardial infarction（STEMI） effect and safety.Methods In November 2008 to 2009 September hospitalization do emergency thrombolysis successful 72 patients were randomly divided into the treatment group（n﹦37）,based on routine treatment,within 24h plus atorvastatin 80mg 1 times every night,drug use 12 months;The control group（n﹦35）,give the acute STEMI conventional thrombolysis,fight against ischemic plugs,such treatment.Two groups of patients observed treatment 4 months follow-up and 1 year clinical situation.Results The treatment group clinical effect better than the control group.Conclusion Early application high-dose atorvastatin and fibrinolytic therapy acute st-elevation myocardial infarction,can reduce the risk of cardiovascular events,improved clinical outcomes;and drug use safer,fewer side effects,did not increase the complications after thrombolysis.
出处
《实用心脑肺血管病杂志》
2011年第7期1109-1111,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
阿托伐他汀
急性ST段抬高心肌梗死
溶栓治疗
心血管事件
Atorvastatin
Acute ST-elevation myocardial infarction
Thrombolytic therapy
Cardiovascular events
