摘要
目的应用放射性核素显像对甲状腺癌术后首次和多次^131I治疗后唾液腺功能的变化进行观察和半定量评价。方法收集56例DTC术后^131I治疗后6个月行唾液腺显像患者，其中21例行首次^131I治疗前及治疗后6个月唾液腺显像。通过计算获得摄取功能参数：4min摄取比值（UR4）和15min摄取比值（UR15）；排泄功能参数：最大排泄量（MS）和酸刺激后腺体计数下降到最低所需的时间（Tmin）。21例首次^131I治疗前后定量参数行配对t检验。将所有唾液腺显像按治疗前、第1次治疗后6个月、第2次治疗后6个月、≥3次治疗后6个月分为4组，各组功能参数进行单因素方差分析和Kruskal-Wallis秩和检验，并对^131I治疗次数与功能参数行Spearman等级相关分析。结果21例首次^131I治疗后6个月，左、右侧腮腺UR15分别下降16％和14％（t值为2．188和3．322，P均〈0．05），腮腺其余参数及颌下腺所有参数与治疗前比较差异均无统计学意义（t值为-0．952～2．039，P均〉0．05）。按治疗次数分组比较，4组腮腺UR4、UR15、MS如下：左侧分别为1．76±0．29，2．60±0．38，（72．8±24．2）％；1．55±0．34，2．15±0．51，（64．4±21．6）％；1．55±0．40，2．02±0．68，（57．2±34．2）％；1．45±0．33，1．69±0．46，（30．6±36．9）％；右侧分别为：1．81±0．33，2．57±0．51，（69．1±18．5）％；1．61±0．38，2．19±0．59，（64．2±25．0）％；1．60±0．42，2．00±0．62，（53．2±41．7）％；1．48±0．38，1．63±0．29，（26．1±45．9）％；组间差异有统计学意义（左右侧UR4、UR15的F值分别为7．018，13．393和3．112，10．194，左右侧MSH=12．240，26．569，P均〈0．05）。Tmin 4组间差异无统计学意义（左右侧H=2．077，3．019，P均〉0．05）。组间两两比较：^131I治疗1次及2次患者与对照组比较仅UR15减低有统计学意义（P均〈0．05
Objective To semiquantify salivary gland damage after ^131I treatment in patients post thyroidectomy using salivary gland scintigraphy. Methods Fifty-six patients underwent salivary gland scintigraphy 6 months after ^131 I ablation therapy following thyroidectomy, including 21 with both baseline （ before ^131I treatment） and follow-up （6 months after the 1^st ^131I treatment） imaging. Salivary gland function was quantified by uptake ratios at 4 minutes （UR4） and 15 minutes （UR15）, and excretory index at maximum secretion （MS）, time duration from stimulation to minimum count （Tmin ）. Paired t test was used for the 21 patients with both baseline and follow-up imaging. All the studies were divided into four groups： before ^131I therapy, after 1^st therapy, after 2Rd therapy, and after 3^rd or more times of therapy. Group differences were evaluated by the one-way analysis of variance （ANOVA）/Kruskal-Wallis test. Spearman test was used to analyze the correlation between the parameters and times of therapy. Results After the ^131I therapy, UR15 for the left and right parotid glands were 16% and 14% lower than the baseline, respectively （t = 2. 188, 3. 322, both P 〈0.05）. All the other parameters were not significantly different from those of baseline （t ： - 0.952 to 2.039, all P 〉 0.05 ）. Among the four groups, significantly different parameters for both parotid glands were found ： UR4, UR15, MS for the left parotid of the four groups were 1.76 ± 0.29, 2.60 ±0.38, （72.8 ±24.2）% ; 1.55 ±0.34, 2.15 ±0.51, （64.4 ±21.6）% ; 1.55 ±0.40, 2.02 ±0.68, （57.2 ±34.2）% ; 1.45 ±0.33, 1.69 ±0.46, （30.6 ±36.9）% ; respectively （F values for UR4 and UR15 were 7.018, 3. 112 and H value for MS was 12. 240, all P 〈 0.05）. UR4, UR15, MS for the right parotid were 1.81 ±0.33, 2.57±0.51, （69.1 ±18.5）%; 1.61 ±0.38, 2.19±0.59, （64.2 ±25.0）%; 1.60± 0.42, 2.00±0.62, （53.2±41.7）%; 1.48 ±0.38, 1.63±0.29, （26.1 ±45.9）%, respectively （F= 13.
出处
《中华核医学杂志》
CAS
CSCD
北大核心
2011年第3期160-163,共4页
Chinese Journal of Nuclear Medicine
基金
基金项目：宜昌市指导性科技研究与开发计划项目（K09-039）
