摘要
目的对比尼莫地平和通络解毒胶囊两种药物治疗脑缺血性损伤的临床疗效。方法 2010年1月～2011年1月进入本院神经内科的脑缺血患者61例,随机分为两组:尼莫地平组和通络解毒胶囊组。尼莫地平组患者给予尼莫地平注射液20mg,3次/d;通络解毒胶囊组患者口服通络解毒胶囊1.0g,3次/d,连续服用15d。检测患者治疗前后血液流变学、中医症状积分等指标。结果 尼莫地平组和通络解毒胶囊组的纤维蛋白原和血小板聚集试验在治疗后有显著变化(P<0.05或P<0.01)。尼莫地平组和通络解毒胶囊组的舒张压、收缩压、血浆α颗粒膜蛋白、D-二聚体和中医症状积分指标都有所下降(P<0.05或P<0.01)。通络解毒胶囊组的全血黏度和血浆黏度有所降低(P<0.05)。与尼莫地平组比较,通络解毒胶囊组改善脑缺血性损伤更明显(P<0.05或P<0.01)。结论通络解毒胶囊治疗脑缺血性损伤具有良好的效果,可提高患者的认知性,安全性高。
Objective To compare of effects between nimodipine and tongluojiedu capsules in treatment of brain ischemic injury. Methods 61 patients with cerebral infarction were divided randomly into two groups. 30 patients were treated with nimodipine and 30 patients were treated with tongluojiedu capsules for 15d. Clinical observation and laboratory examinations were performed before and af- ter the treatment. Results Fibrinogen and platelet aggregation in nimodipine group and tongluojiedu capsule group changed significantly after treatment（P〈0.05 or P〈0.01）. Diastolic blood pressure, systolic blood pressure, plasma or-granule membrane protein, D-dimer and scores of clinical symptoms in two groups had decreased （P〈0.05 or P〈0.01 ）. Tongluojiedu capsule group＇s blood viscosity and plasma viscosity were lower （P〈0.05）. Compared with nimodipine, the tongluojiedu capsules had better effect on cerebral ischemia （P〈0.05 or P〈0.01）. Conclusion Tongluojiedu capsule is an effective Chinese medicine for treating cerebral infarction.
出处
《中国现代医生》
2011年第18期95-96,108,共3页
China Modern Doctor
基金
浙江省中医药重点项目研究计划(项目编号:2009ZA002)
