摘要
目的探讨血小板内皮细胞黏附分子-1(platelet endothelial cell adhesion molecule-1,PECAM-1)和高敏C反应蛋白(hs-CRP)水平变化与老年慢性左心力衰竭严重程度的相关性。方法根据NYHA心功能分级和左心室射血分数(LVEF)将健康对照者和老年慢性左心力衰竭患者分为对照组[LVEF(63.97.0±4.65)%]、Ⅰ级组[LVEF(42.67±2.06)%]、Ⅱ级组[LVEF(34.26±3.17)%]、Ⅲ级组[LVEF(29.05±1.07)%]和Ⅳ级组[LVEF(25.17±1.42)%]。采用流式细胞仪检测健康对照者和老年慢性左心力衰竭患者PECAM-1的表达。应用散射免疫比浊法测定hs-CRP的水平。结果随着NYHA心功能分级的升高和LVEF的下降,PECAM-1和hs-CRP的水平明显上升。结论 PECAM-1和hs-CRP的水平显著升高可能参与了老年慢性左心力衰竭发生发展的机制。
Objective To study the relationship between expression of circulating platelet endothelial cell adhesion molecule-1（PECAM-1） and high-sensitivity C-reactive protein（hs-CRP） and various degrees of chronic left heart failure in elderly patients.Methods According to New York Heart Association（NYHA） class and left ventricular ejection fraction（LVEF）,the healthy subjects and the patients were divided into five groups： control[LVEF（63.97.0±4.65）%],classⅠ[LVEF（42.67±2.06）%],classⅡ[LVEF（34.26±3.17）%],class Ⅲ[LVEF（29.05±1.07）%] and class Ⅳ[LVEF（25.17±1.42）%].The expression of circulating PECAM-1 of the patients and healthy subjects was measured by flow cytometry and the level of hs-CRP was measured by nephelometry immunoassay.Results It showed that the levels of circulating PECAM-1 and hs-CRP were elevated significantly with severe chronic left heart failure in elderly patients.Conclusion The study shows the upregulation of circulating PECAM-1 and hs-CRP may contribute to the development of chronic heart failure in elderly.
出处
《实用临床医药杂志》
CAS
2011年第9期25-28,共4页
Journal of Clinical Medicine in Practice
关键词
慢性左心力衰竭
老年人
血小板内皮细胞黏附分子-1
高敏C反应蛋白
left heart failure
chronic
the elderly
platelet endothelial cell adhesion molecule-1
high-sensitivity C-reactive protein
