摘要
目的观察参麦注射液对急性肺挫伤患者炎性细胞因子肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)的影响。方法选择70例急性肺挫伤患者,随机分为对照组和治疗组,各35例。两组均给予常规西医治疗,治疗组在此基础上加用参麦注射液治疗,两组疗程均为7 d。观察急性肺挫伤患者平均住院时间、肺部感染率、急性呼吸窘迫综合征(ARDS)发生率,比较两组患者血清TNF-α、IL-6、IL-8变化情况。结果治疗组患者平均住院时间、肺部感染率、ARDS发生率均较对照组明显降低(P均<0.05);治疗7 d后,治疗组患者血清TNF-α、IL-6、IL-8水平较对照组有明显降低(P<0.05或P<0.01)。结论参麦注射液能显著减少急性肺挫伤患者炎性细胞因子TNF-α、IL-6、IL-8的产生,抑制炎症反应。
Objective To observe the effects of shenmai injection on tumor necrosis factor-α（TNF-α）、Interleukin-6（IL-6） and Interleukin-8（IL-8） levels in patients with acute pulmonary contusion.Methods 70 patients with acute pulmonary contusion were randomly divided into routine treatment group（n=35） and shenmai injection treatment group（n=35）.Both groups were given routine treatment,while the patients of shenmai injection treatment group were given shenmai injection in addition,for 7 day.Average stay,incidence of pulmonary infection and respiratory distress syndrome（ARDS） in patients with acute pulmonary contusion were observed.The changes of serum TNF-a,IL-6 and IL-8 levels were compared in both groups.Results The average stay,incidence of pulmonary infection and ARDS（P0.05） in shenmai injection treatment group were significantly decreased,the serum TNF-α、IL-6 and IL-8 levels in shenmai injection treatment group were lower than those in routine treatment group（P0.01 or P0.05） after 7 day.Conclusion shenmai injection can significantly reduce the production of inflammatory cytokins,TNF-α、IL-6 and IL-8 levels in patients with acute pulmonary contusion,and inhibiting inflammatory reaction.
出处
《临床军医杂志》
CAS
2011年第3期469-471,共3页
Clinical Journal of Medical Officers
关键词
参麦注射液
急性肺挫伤
炎性细胞因子
shenmai injection
acute pulmonary contusion
inflammatory cytokins
