摘要
目的：测定冠心病患者血栓调节蛋白（Thrombomodulin,TM）及高敏C反应蛋白（high- sensitive C-reactive protein,hs-CRP）水平,并探讨其与冠心病近期（18个月左右）急性事件的关系.方法：检测冠心病患者（包括急性冠脉综合征亚组、稳定型心绞痛亚组）血浆TM、hs-CRP浓度,并进行18个月的随访,追踪其治疗情况及有无近期急性事件发生,用多因素logistic回归分析TM、hs-CRP与冠心病近期急性事件的关系.结果：TM（P=0.009,OR=14.492）、CRP（P=0.045,OR=2.801）均与急性冠脉综合征亚组近期急性事件明显相关,TM具有更强的相关性;而在稳定型心绞痛亚组中,TM、CRP均与近期急性事件无明显相关.结论：血浆TM、hs-CRP 水平均可预测急性冠脉综合征患者近期急性事件的发生,相对于hs-CRP而言,TM可能具有更强的预测价值.
Objective To determine the thrombomodulin （TM） and high--sensitive C--reactive protein （hs--CRP） levels in patients with coronary heart disease, and investigate its association with coronary heart disease short--term （about 18 months） acute events. Methods： Plasma TM and hs--CRP concentration of coronary artery disease patients （including acute coronary syndrome subgroups and stable angina subgroup） were detected and followed-- up for 18 months, the treatment and short--term acute events were recorded. Multivariate logistic regression analysis was used to explore the relationship between TM, hs--CRP and coronary heart disease short--term acute events. Results TM （P = 0. 009, OR = 14. 492） and CRP （P = 0. 045, OR = 2. 801） were significantly associated with short--term acute events in acute coronary syndrome subgroup, and the relevance was more prominent with TM; no significant correlation was found in stable angina subgroup. Conclusion Plasma TM and hs--CRP levels can predict the short--term acute events in patients with acute coronary syndrome, TM may have stronger predictive potency compared with hs--CRP.
关键词
冠心病
血栓调节蛋白
高敏C反应蛋白
Coronary heart disease
Thromhus regulatory protein
Gao min e-- reactive protein
