摘要
目的观察胰岛素强化治疗前后合并抑郁情绪的糖尿病患者性激素水平变化及其与情绪变化的相关性。方法选择187例2型糖尿病患者（T2DM）,给予胰岛素强化治疗3个月,对入选患者治疗前后进行抑郁测定,化验其血糖、糖化血红蛋白（HbA1c）、血清性激素,并进行统计学处理。治疗期间空腹血糖（FBG）控制在4.4-6.1mmol/L,餐后2小时血糖（PBG2h）控制在4.4-8.0mmol/L之间。结果胰岛素治疗前合并抑郁情绪的男性促黄体生成素（LH）和女性泌乳素（PRL）、促卵泡生成素（FSH）明显高于无抑郁情绪患者,男性和女性雌二醇（E2）抑郁情绪患者明显低于无抑郁患者（P〈0.01）,睾酮（T）两者无显著差异（P〉0.05）;治疗后合并抑郁情绪患者抑郁指数较治疗前明显降低,合并抑郁情绪的男性LH、E2和女性PRL、FSH、E2较治疗前差异有显著性（P〈0.01）。治疗前抑郁指数与男性LH和女性PRL、FSH正相关（r=0.565,0.478,0.617,P〈0.01）,与男性和女性E2呈负相关（r=-0.614,-0.527,P〈0.05）;治疗后抑郁指数下降与男性LH和女性PRL、FSH下降正相关（r=0.425,0.398,0.326,P〈0.05）,与男性和女性E2升高呈负相关（r=-0.357,-0.411,P〈0.05）。结论胰岛素治疗可以显著改善2型糖尿病患者抑郁情绪,并且与性激素水平变化相关。
Objective To observe the change of sex hormones levers on depression in diabetic patients and the correlation of change of sex hormones levels with depression before and after insulin treatment.Methods A total of 187 patients with type 2 diabetic mellitus（T2DM） were intensively treated with insulin for 3 months of treatment.We tested all patient＇s depression,blood glucose,HbA1c,sex hormones levels before and after treatment.Results LH in male and PRL,FSH in female were highter and E2 in both the male and female were lower in comorbid depression patients than those who had no comorbid depression before treatment（P〈0.01）.Depression degree were decreased after insulin treatment.Depression degree were positively correlated with LH in male and PRL,FSH in female（r=0.565,0.478,0.617,P〈0.01） and were negatively correlated with E2 in both the male and female（r=-0.357,0.411,P〈0.05） before insulin treatment.Decline of depression degree were positively correlated with decrease of LH in male and PRL,FSH in female（r=0.425,0.398,0.326,P〈0.05） and were negatively correlated with increase of E2 in both the male and female（r=-0.357,-0.411,P〈0.05）after insulin treatment.Conclusion The intensive insulin treatment can improve depression in T2DM,and the change were correlation with sex hormones levers.
出处
《中国健康心理学杂志》
2011年第5期540-542,共3页
China Journal of Health Psychology
关键词
糖尿病
胰岛素
抑郁
性激素
心理测评
Type 2 diabetes
Insulin
Depression
Sex hormones
Psychological assessment
