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慢性心力衰竭患者血浆N末端脑利钠肽水平变化 被引量:4

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摘要 目的观察血浆N末端脑利钠肽(NT-proBNP)水平在不同左心室射血分数(LVEF)慢性心力衰竭患者中的变化。方法选择356例慢性心力衰竭患者,彩色超声心动图测定左心室射血分数(LVEF),免疫荧光法测定血浆NT-proBNP水平,分析血浆NT-proBNP与LVEF及年龄、性别的关系。结果根据彩色超声心动图测得的LVEF值分为Ⅰ、Ⅱ、Ⅲ、Ⅳ组,LVEF值分别为:大于45%、35%~45%、25%~35%及小于25%4组,血浆NT-proB-NP中位数分别为375(186~2476)ng/L、476(278~6752)ng/L、896(247~9000)ng/L和3472(1326~9000)ng/L,与Ⅰ组相比,差异均有统计学意义(均为P<0.05);据年龄分为≤50岁、51~60岁、61~70岁及≥71岁4组,各组血浆NT-proBNP中位数分别为:男性295(190~6579)ng/L、502(263~8634)ng/L、11 396(303~8956)ng/L和1785(335~9102)ng/L,女性286(186~6412)ng/L、479(235~8589)ng/L、1361(289~8879)ng/L和1713(314~8956)ng/L,与≤50岁组相比,其余各组差异均有统计学意义(均为P<0.05),但性别间无统计学意义(均为P>0.05)。结论血浆NT-proBNP水平不仅是慢性心力衰竭的重要诊断标准,而且与心力衰竭严重度及年龄有良好的相关性。
出处 《中国心血管杂志》 2011年第3期209-210,共2页 Chinese Journal of Cardiovascular Medicine
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同被引文献48

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