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联合检测明胶酶B与甲胎蛋白及总胆汁酸在原发性肝癌诊断中的应用 被引量:10

Joint detection of MMP-9,AFP,and TBA applied in diagnosis of primary liver cancer
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摘要 目的探讨联合检测明胶酶B(MMP-9)、甲胎蛋白(AFP)和总胆汁酸(TBA)在原发性肝癌诊断中的临床意义。方法 40例原发性肝癌患者均为医院2007年1月-2010年6月住院患者,同期选择30例健康体检者作为对照组,分别采用循环酶法检测TBA、采用放射免疫法检测AFP,采用双抗夹心ABC-ELISA法检测MMP-9,并通过统计学方法进行比较分析。结果原发性肝癌组MMP-9、AFP、TBA明显高于健康对照组,差异有统计学意义(P<0.01);三项肿瘤标记物联合测定的阳性率为90.0%,明显高于单项分别测定MMP-9、AFP和TBA阳性率,其阳性率分别为30.0%、80.0%和50.0%,差异有统计学意义(P<0.05),且单项测定AFP的阳性率又明显高于MMP-9、TBA的阳性率,差异有统计学意义(P<0.05)。结论血清AFP联合MMP-9和TBA检测可明显提高原发性肝癌的阳性检出率,对原发性肝癌的早期诊断具有重要的临床意义。 OBJECTIVE To evaluate the combined detection of MMP-9,AFP,and TBA in the diagnosis of primary liver cancer clinical significance.METHODS A total of 40 cases of primary liver cancer patients in our hospital from Jan2007 to Jun 2010 hospitalized patients were selected,30 healthy cases over the same period were selected as the control group.Enzymatic cycling radioimmunoassay and double-antibody sandwich ABC-ELISA assay were employed to respectively detect TBA,AFP and MMP-9,then they were compared through statistical methods.RESULTS MMP-9,AFP and TBA of primary liver cancer group were significantly higher than that of the control group,the differences were statistically significant(P0.01).The positive rate of three tumor markers combined determination was 90.0%,which was significantly higher than that of individual determination of MMP-9(30.0%),AFP(80.0%) and TBA(50.0%)(P0.05),and the positive rate of individual determination of AFP was obviously higher than that of MMP-9 and TBA,the differences were statistically significant(P0.05).CONCLUSION Serum MMP-9 and AFP TBA joint detection can improve the positive rate of primary liver cancer and has important clinical significance in early diagnosis of primary liver cancer.
出处 《中华医院感染学杂志》 CAS CSCD 北大核心 2011年第12期2641-2642,共2页 Chinese Journal of Nosocomiology
关键词 原发性肝癌 明胶酶B 甲胎蛋白 总胆汁酸 Primary liver cancer MMP-9 AFP TBA
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