摘要
通过在蛙皮缩胆囊素（ｃａｅｒｕｌｅｉｎ ，Ｃｎ） 诱导的轻症胰腺炎时用阿片类止泻剂（ｌｏｐｅ ｍｉｎ） 抑制肠运动和在脱氧胆酸胰管注射的重症胰腺炎时用大黄促进肠运动的两个系列鼠实验为基础，探讨了肠道运动力学改变对急性胰腺炎的病程和预后的影响。结果显示： 抑制运动将增加胰腺炎的继发感染和内毒素血症，反之促进肠运动则减少细菌移位和内毒素血症，从而降低实验大鼠的死亡率。提示： 肠动力学改变与急性胰腺炎的病程及预后有密切关系，通过促进肠道运动可减少急性胰腺炎的继发感染和多器官衰竭，从而改善胰腺炎的预后。
This study based on two serial animal experiments: ①caerulein induced edematous pancreatitis with gut motility inhibited by administration of lopemin (an opium antidiarrheal agent) and ②deoxycholate intraductal injection induced pancreatitis with gut motility improved by administration of rhubarb solution. The results of these experiments indicated that inhibition of gut motility will increase the incidence of bacterial translocation and endotoxemia during acute pancreatitis; and acceleration of gut motility will significantly decrease the incidence of bacterial translocation and endotoxemia during severe type of acute pancreatitis. The authors conclude that promotion of gut motility may protect the inflammatory pancreas from infection and prevent the multiple organ failure during acute pancreatitis, and eventualy improve the prognosis of pancreatitis.
出处
《中国普外基础与临床杂志》
CAS
1999年第6期325-327,共3页
Chinese Journal of Bases and Clinics In General Surgery
关键词
急性
胰腺炎
肠运动
细菌移位
内毒素血症
Acute pancreatitis Gut motility Bacterial translocation Endotoxemia
