摘要
目的探讨β-连环蛋白(β-catenin)和腺瘤样的结肠息肉病(APC)蛋白在宫颈上皮内瘤样变及宫颈鳞癌中的表达及意义。方法采用免疫组化二步法检测β-catenin和APC蛋白在30例宫颈鳞癌、50例宫颈上皮内瘤样变及24例正常宫颈组织中的表达。结果①β-catenin和APC蛋白阳性表达率在正常宫颈组织,宫颈上皮内瘤样变及宫颈浸润鳞癌3组间均有显著差异(P<0.05)。②β-catenin和APC蛋白阴性表达率在CINⅠ、CINⅡ、CINⅢ三组之间比较无统计学差异(P>0.05),β-catenin在CINⅠ组与CINⅡ-CINⅢ组二者之间差异有统计学意义(P<0.05)。③β-catenin阴性表达与APC蛋白阴性表达呈显著正相关(P<0.05)。结论联合检测β-catenin与APC蛋白的表达情况可能有助于宫颈癌的诊断和治疗。
Objective To study the expression and role of β-catenin and APC in cervical squamous cell carcinoma and cervical intraepithelial neoplasia.Methods The expression of β-catenin and APC protein was detected using immunohistochemistry in 30 cases of cervical squamous cell carcinoma,50 cases of cervical intraepithelial neoplasia,and 24 cases of normal cervix tissue.Results ①The abnormal expression of β-catenin and APC in normal cervical mucosa,CIN and cervical squamous cell carcinoma among the three groups were significantly different（P0.05）.②The positive rate of β-catenin and APC among CIN1,CIN2,CIN3 was not statistically significant（P0.05）.But the difference ofβ-catenin between low-level CIN and high-level CIN is significant（P0.05）.③A significantly positive relationship was observed between β-catenin and APC protein expression in cervical carcinoma（P0.05）.Conclusion β-catenin protein and APC protein are appeared in the abnormal expression in the CIN and cervical carcinoma.They play a certain role in the cervical carcinoma occurrence and development.
出处
《临床和实验医学杂志》
2011年第12期915-917,共3页
Journal of Clinical and Experimental Medicine
