摘要
目的探讨支气管肺泡灌洗(BALF)在弥漫性肺实质疾病(DPLD)预后评估中的价值。方法回顾分析27例弥漫性肺实质疾病患者临床资料及BALF结果,对该组患者进行随访,观察BALF中细胞成分与预后的关系。结果 IPF5例,COP4例,NSIP7例,HP5例,CVD-ILD6例,病情缓解13例,加重3例,死亡11例;淋巴细胞比例与中性粒细胞比例与生存时间的COX回归分析显示淋巴细胞百分比为保护因素(OR=0.950,95%可信区间0.913～0.990,P=0.018)。中性粒细胞百分比为危险因素(OR=1.023,95%可信区间0.998～1.042,P=0.064)。结论 BALF在DPLD诊断及预后评估中具有重要价值,淋巴细胞增高为保护因素,中性粒细胞增高为危险因素。
Objective To assess the value of bronchoalveolar lavage fluid（BALF） in the prognosis implications of diffuse parenchymal lung diseases（DPLD）.Methods Clinical data and BALF of DPLD 27 patients were analyzed retrospectively,subsequent follow-ups were performed.We observed the relationship between BALF findings and its＇ corresponding prognosis.Results 5 cases of IPF,4 cases of COP,7 cases of NSIP,5 cases of HP,6 cases of CVD-ILD.Among them 13 patients relieved,3 patients aggravated and 11 patients died as follow-up.Analysis of relationship between BALF and prognosis with COX Regression showed that the proportion of lymphcyte was the protective factor（OR=0.950,95% CI 0.913~0.990,P=0.018）,and the proportion of neutrophil was the risk factor（OR=1.023,95% CI 0.998~1.042,P=0.064）.Conclusion The constituent ratio of cells in BALF is valuable for the prognosis evaluation of DPLD.It is more significantly for the high proportion of lymphocytes to indicate the well prognosis than the high proportion of neutrophils to indicate the bad prognosis in these patients.
出处
《中国现代医药杂志》
2011年第5期49-51,共3页
Modern Medicine Journal of China
关键词
支气管肺泡灌洗
弥漫性肺实质疾病
Bronchoalveolar lavage fluid Diffuse parenchymal lung diseases
