摘要
为探讨一氧化氮（ Ｎ Ｏ） 在脑梗塞患者中的作用，应用荧光分光光度法测定１５ 例脑梗塞患者和１０ 例对照组脑脊液中 Ｎ Ｏ 的浓度，同时测量脑梗塞体积并对神经机能缺损程度进行评分。结果发现：脑梗塞患者脑脊液中 Ｎ Ｏ 浓度较对照组明显升高（ Ｐ ＜ ０ ．０５） ； Ｎ Ｏ 浓度与脑梗塞体积大小呈正相关（ ｒ ＝ ０ ．５７ ， Ｐ ＜ ０ ．０５ ） ，与神经机能缺损程度亦呈正相关（ ｒ ＝ ０ ．５４ ， Ｐ ＜ ０ ．０５ ） 。本结果支持脑缺血后产生的 Ｎ Ｏ可加重缺血性脑损害。
To study the role of the nitric oxide(NO) in patients with cerebral infarction, NO in cerebrospinal fluid was determined in cerebral infarction group(15 cases) and control group(10 cases). Infarct volume was determined by CT between the second and the 7th day after the onset of symptoms. The severity of neurological deficits was assessed with the stroke scale of Ministry of Public Healthy(China). The results showed that NO was higher in cerebral infarction group (3.12±1.60) than that in control group(1.19±1.01)(P<0.01). The concentration of NO was positively correlated with infarction volume(r=0.57,P<0.05) and severity of neurological of deficits(r=0.54,P<0.05), respectively. The results support the conclusion that NO produced in large amounts in the postischemic tissue contributes to the progression of the brain damage, which was demonstrated in animal models of focal cerebral ischemia.
出处
《湖南医科大学学报》
CSCD
1999年第4期374-376,共3页
Bulletin of Hunan Medical University
