摘要
３０ 只日本雄性大耳兔，随机等分为２ 组。缺血预处理组先采用左肺门阻断１０ ｍｉｎ ，开放再灌注１５ ｍｉｎ 的肺缺血预处理，然后阻断左肺门６０ ｍｉｎ ，开放再灌注６０ ｍｉｎ ，对照组未采用预处理。结果示在再灌注后６０ ｍｉｎ ，预处理组血中血管紧张素Ⅱ含量、动脉氧分压及肺组织中超氧化物歧化酶含量较对照组明显增加，而平均肺动脉压和肺组织的丙二醛含量及肺泡损伤较对照组明显减低。提示缺血预处理能减轻在体兔肺缺血再灌注损伤。
Thirty male Japanese white rabbits were randomized into two groups. Fifteen rabbits were treated with ischemic preconditioning(their left lung hilus clamped for 10?min and released for 15?min; Group IP). Fifteen rabbits were not treated with ischemic preconditioning(Group C). Then the left lung hilus of both groups were occlused for 60?min and reperfused for 60?min. The results were that after 60?min of reperfusion, in Group IP, the contents of angiotensin Ⅱ(AngⅡ) and artery oxygen tension(PaO 2) in blood samples and the contents of superoxide dismutase in lung tissue were significantly higher, while the mean pulmonary artery pressure in blood samples, the wet/dry ratio and malondialdehyde content in lung tissue were significantly lower than those in Group C; Histological findings showed less damage in Group IP. It is suggested that lung ischemic preconditioning can reduce normothermic rabbit lung ischemia reperfusion injury.
出处
《湖南医科大学学报》
CSCD
1999年第4期319-321,共3页
Bulletin of Hunan Medical University
关键词
肺缺血
缺血预处理
再灌注损伤
兔
plumonary
ischemic preconditioning *
reperfusion injury
angiotensin Ⅱ
rabbits
