摘要
目的探讨进行性色素性紫癜性皮病的发病原因、临床特点和治疗方案,提高对本病的认识。方法回顾性分析本科1995年1月-2010年10月收治的27例进行性色素性紫癜性皮病患者的临床和实验室检查资料。结果 27例患者中男女比例为1.7:1,15例(55.56%)合并有基础疾病。18例(66.67%)皮损位于双下肢,6例患者(22.22%)累及四肢,3例患者(11.11%)累及四肢、臀部和躯干,糖皮质激素、雷公藤多甙、沙利度胺、氨苯砜等不同药物联合治疗后21例患者皮损消退,6例患者皮损大部分消退。其中19例患者出现反复复发。结论进行性色素性紫癜性皮病病程慢性、易复发,目前尚无特效治疗;糖皮质激素、雷公藤多甙、沙利度胺、氨苯砜等治疗均有效,且以糖皮质激素效果明显,但不能预防复发,光疗可作为一有效而安全的联合或单独治疗选择。
Objective To improve the recognition of clinical feature of progressive pigmented purpuric dermatosis （Schambergs＇ disease）. Methods The clinical data of 27 cases of progressive pigmented purpuric dermato- sis collected from dermatology department of the First Affiliated Hospital of Kunming Medical College from January 1995 to October 2010, were retrospectively analyzed on their etiology ,clinical features and efficiency of treatment retrospectively. Results The results showed ratio of male/female was 1.7： 1, and fifteen cases （55.56%） had other underlying diseases. Lesions of 18 patients were limited on the lower extremity （66.67%）, lesions of 6 patients were involved with their extremitis （22. 22%）, 3 patients＇ lesions （ 11.11% ）located disseminatedly. Patients responded to the combinations of the various drugs including corti- costeroid, tripterygium hypoglaucum, thalidone, DDS, and so on. Lesions of 21 cases cleared, lesions of 6 cases cleared considerably and 19 cases recurred repeatedly. Conclusion The disease usually runs a chronic and relapsing course. Glucocorticoid, ripterygium hypoglaucum, thalidone, and DDS are the main therapeutic drugs for Schambergs＇ disease, but they can＇t prevent recurrences. Glucocorticoid is effective but is not recommend as the first choice. Narrowband UVB can be a good alternative in the treatment of Schambergs＇ disease.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2011年第6期448-449,456,共3页
The Chinese Journal of Dermatovenereology
关键词
进行性色素性紫癜性皮病
临床分析
Progressive pigmented purpuric dermatosis
Clinical analysis
