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自噬及其与疾病和凋亡的关系 被引量:6

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摘要 自噬是由Ashford和Porter在1962年提出的。它是指从粗面内质网的无核糖体附着区脱落的双层膜包裹部分胞质和细胞内需降解的细胞器、蛋白质等成分形成自噬体,并与溶酶体融合形成自噬溶酶体,降解其所包裹的内容物,以实现细胞本身的代谢需要和某些细胞器的更新。自噬受多种途径的调节,并与心脏疾病、肿瘤、神经变性疾病等诸多疾病息息相关。
作者 杨礼 周海燕
出处 《中华医学杂志》 CAS CSCD 北大核心 2011年第18期1292-1294,共3页 National Medical Journal of China
基金 浙江省科技厅科研课题(2008C23056)
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参考文献29

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