摘要
目的探讨测定血清白三烯B4浓度在诊断和治疗儿童哮喘中的临床意义。方法观察组:65例哮喘儿童按病情分为:轻度发作组29例,平均年龄(9.1±2.8)岁;中度发作组22例,平均年龄(8.5±1.9)岁;重度发作组14例,平均年龄(8.7±2.3)岁。对照组:同期住院的下呼吸道感染但无喘息症状的5岁以上患儿30例,男17例,女13例,平均年龄(8.5±1.8)岁。测定各组患儿血清LTB4浓度,观察组患儿同时测定肺功能PEF及FEV1,测得值以占预计值百分比计算。采用方差分析、q检验、t检验和直线相关分析。结果观察组患儿血清LTB4平均浓度(67.1±26.8)pg/ml,显著高于对照组(P<0.01)。在观察组中有特应体质患儿占61.5%(40/65),其血清LTB4浓度(74.1±28.5)pg/m1,显著高于非特应体质患儿(P<0.01)。观察组患儿中哮喘发作程度愈重,血清LTB4浓度愈高(P<0.01),其肺功能PEF及FEV1占预计值的百分比下降愈明显(P<0.01)。不同发作程度的哮喘患儿的LTB4与PEF、FEV1值均呈负相关(r=-0.39,-0.41,均P<0.01)。结论血清LTB4测定有助于儿童支气管哮喘的诊断及疾病严重程度的判定。
Objective To detect serum LTB4 concentration in children with asthma.Methods Asthmtic group：65 children with asthma were randomly divided into three subgroups：（1）light attack group（aged 9.1±2.8years old）;（2） moderate attack group（8.5±1.9years old）;（3）serious attack group（8.7±2.3years old）.Non-asthmtic group：30 non-asthmatic children with respiratory infection in hospital.Comparitions about LTB4,PEF and FEV1 were made among these groups.Results The serum LTB4 concentration of asthmtic group was 67.1±26.8pg/m1,which was higher than that of the non-asthmtic group（P0.01）.61.5%（40/65） children in asthmtic group were atopy,which had a higher serum LTB4 concentration of 74.1±28.5pg/m1（P0.01）.The more serious the asthma attacked,the higher the serum LTB4 concentration were detected,and the more the PEF% and FEV1% were descending（P0.01）.There was a negative linear correlation with serum LTB4 concentration and PEF%（r=-0.39,P0.01）,also a negative linear correlation with serum LTB4 concentration and FEV1%（r=-0.41,P0.01）.Conclutions Serum LTB4 concentration in children with asthma maintained a high leve1,which could help to make a diagnosis and judge the condition of asthma.
出处
《当代医学》
2011年第17期4-5,共2页
Contemporary Medicine
