摘要
目的 研究血脂康对高脂血症患者血脂的调脂作用及对血栓素A2 (TXA2 )、前列环素(PGI2 )的影响。方法 91例原发性高脂血症患者随机分为血脂康组和吉非罗齐对照组 ,分别口服血脂康 1.2g/d或吉非罗齐 1.2g/d ,连服 8周 ,治疗前后测定血脂谱、TXB2 、6 酮 前列腺素F1α( 6 Keto PGF1α)。结果 ( 1)服血脂康和吉非罗齐 8周后 ,血清总胆固醇 (TC)分别降低 2 1.6%和 2 0 .4 % ,甘油三酯 (TG)分别降低 2 3 .3 %和 4 0 .3 % ,低密度脂蛋白胆固醇 (LDL C)分别降低 3 3 .3 %和 2 4 .8% ,高密度脂蛋白胆固醇 (HDL C)分别升高 3 3 .7%和 2 6.9% (以上P均 <0 0 1) ,血脂康降低TG的作用弱于吉非罗齐 (P <0 .0 5 ) ,而其降低TC、LDL C和升高HDL C的作用与吉非罗齐比较差异无显著性 (P均 >0 0 5 )。 ( 2 )血脂康可使血浆脂蛋白 (a) [LP(a) ]含量降低 2 8.2 % (P <0 .0 1) ,而吉非罗齐仅降低 4 .9%(P >0 .0 5 ) ;血脂康的作用强于吉非罗齐 (P <0 .0 1)。 ( 3 )血脂康和吉非罗齐使血浆TXB2 含量分别降低 3 4.2 %和 8.4 % (P均 <0 .0 1) ,而且血脂康的作用强于吉非罗齐 (P <0 .0 1) ;血脂康和吉非罗齐使血浆 6 Keto PGF1α含量分别升高 65 .4 %和 11.7% (P均 <0 .0 1) ,血脂康的作用强于吉非罗齐 (P <0 .0 1)。
Objective To study the effects of Xuezhikang on lipid profile, thromboxane(TX) A 2、prostacyclin(PGI 2) in patients with hyperlipoidemia. Methods 91 patients with hyperlipoidemia were randomly divided into a treatment group ( n =47, Xuezhikang 1.2 g/d Bid, p.o) and control group ( n =44, gemfibrozil 1.2 g/d Bid, p.o). serum lipids、TXB 2 and 6 Keto PGF 1α were determined before and 8 weeks after the treatment. Results (1)After 8 weeks of treatment, the level of serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL C) decreased by 21.6% ( P <0.01) and 33.3% ( P <0. 01) in the Xuezikang group and by 20.4% ( P <0.01) and 24.8%( P <0.01) in the gemfibrozil group respectively. Serum high density lipoprotein cholesterol (HDL C) level elevated by 33.7% in the Xuezhikang group ( P <0.01) and 26.9% in the gemfibrozil group ( P <0.01). The effect of Xuezhikang was the same as gemfibrozil. There was no statistically significant difference between the effects of these two drugs. Triglyceride(TG) level decreased by 23.3% in the Xuezhikang group ( P <0.01) and 40.3% in the gemfibrozil group( P <0.01).TG lowering effect of gemfibrozil was superior to that of Xuezhikang ( P <0.05). (2)The level of lipoprotein (a) [LP(a)] in the plasma decreased by 28.2%( P <0.01) in the Xuezhikang group and by 4.9%( P >0.05) in the gemfibrozil group.LP(a) lowering effect of Xuezhikang was superior to that of gemfibrozil( P <0.01). (3)The Level of thromboxane (TX) B 2 in the plasma decreased by 34.2% in the Xuezhikang group ( P <0.01) and by 8.4% in the gemfibrozil group ( P <0.01). TXB 2 lowering effect of Xuezhikang was superior to that of gemfibrozil( P <0.01). The level of 6 KetO PGF 1α in the plasma elevated by 65.4% in the Xuezhikang group( P <0.01) and by 11.7% in the gemfibrozil group ( P <0.01);the effect of Xuezhikang was superior to that of gemfibrozil( P <0.01). Conclusion Xuezhikang could markedly decrease the level of TC and LDL C
出处
《中华内科杂志》
CAS
CSCD
北大核心
1999年第8期517-519,共3页
Chinese Journal of Internal Medicine
