摘要
目的探讨不同时点血浆促肾上腺皮质激素(ACTH)和皮质醇变化在急性脑梗死患者中的临床意义。方法采用电化学发光法检测62例急性脑梗死患者(脑梗死组)和60例健康体检者(健康对照组)8:00、16:00、24:00的血浆ACTH和皮质醇水平,并进行比较。结果急性脑梗死组8:00、16:00、24:00血浆ACTH水平高于健康对照组[(20.5±4.2)pmol/L比(10.4.4±2.6)pmol/L,(18.9±4.9)pmol/L比(8.5±2.1)pmol/L,(18.1±3.8)pmol/L比(7.1±2.4)pmol/L],皮质醇水平也明显高于健康对照组[(542±76)nmol/L比(469±65)nmol/L,(528±43)nmol/L比(341±33)nmol/L,(499±32)nmol/L比(196±27)nmol/L],差异均有统计学意义(P〈0.05)。随病情的加重,急性脑梗死患者各时点血浆ACTH和皮质醇水平显著升高(P〈0.05);预后好者不同时点血浆ACTH和皮质醇水平均明显低于预后差者(P〈0.05)。结论不同时点血浆ACTH和皮质醇的检测,对判断急性脑梗死患者的病情及预后具有重要的临床意义。
Objective To investigate the clinical significance of plasma adrenocorticotropic hormone and cortisol changes at different time in acute cerebral infarction. Methods The clinical data of 62 patients with acute cerebral infarction (acute cerebral infarction group) were analyzed retrospectively, and 60 healthy cases in the same period were recruited as control group. The plasma adrenocorticotropic hormone and cortisol levels at 8:00,16:00 and 24:00 of two groups were detected by immunoassay. Results Plasma adrenocorticotropic hormone and cortisol levels at 8:00, 16:00 and 24:00 in acute cerebral infarction group were significantly higher than those in control group [ (20.5±4.2) pmol/L vs. ( 10.4 ± 2.6) pmol/L, ( 18.9 ± 4.9) pmol/L vs. (8.5 ± 2.1) pmoFL, ( 18.1 ± 3.8) pmol/L vs. (7.1 ± 2.4) pmol/L and (542±76) nmol/L vs.(469 ± 65) nmol/L, (528 ± 43) nmol/L vs. (341 ± 33) nmol/L, (499 ± 32) nmol/L vs. ( 196 ± 27 ) nmol/L ] (P 〈 0.05 ) ; plasma adrenocortieotropic hormone and cortisol levels of severe degree acute cerebral infarction at different time were higher than those of light conditions (P 〈 0.05 ) ; plasma adrenocorticotropic hormone and cortisol levels at different time of acute cerebral infarction patients with good prognosis were significantly lower than those of the persons with poor prognosis (P 〈0.05). Conclusion Plasma adrenoeorticotropic hormone and cortisol testing at different time has clinical significance in determining the condition and prognosis of patients with acute cerebral infarction.
出处
《中国医师进修杂志》
2011年第16期7-9,共3页
Chinese Journal of Postgraduates of Medicine
关键词
脑梗塞
促肾上腺皮质激素
氢化可的松
Brain infarction
Adrenocorticotropic hormone
Hydrocortisone