摘要
目的验证抗乙肝胎盘转移因子(PSTF)的临床疗效和不良反应。方法以胎盘转移因子(PTF)及猪苓多糖加乙肝疫苗为对照,进行“多中心”临床研究。采用随机分组,双盲对照治疗慢性乙型肝炎共346例,疗程均为 3个月。结果 PSTF改善症状和体征、恢复肝功能均优于猪苓多糖加乙肝疫苗。 PSTF组 HBsAg、 HBeAg及 HBV DNA的阴转率分别达4.3%、 53.0%及 53.3%; PTF组分别为0、 22.5%及 26.5%;猪苓多糖组分别为 0、27.6%及27.0%,差异显著。随访结果与治疗结束时相似,未观察到PSTF有任何不良反应。结论PSTF是治疗慢性乙型肝炎、抗乙型肝炎病毒的安全有效药物。
Objective To evaluate the therapeutic efficacy and side effecs of antihepatitis B placenta transfer factor(PSTF). Methods 346 cases of chronic hepatitis B patients were divided at random into three groups, PSTF group, placenta transfer factor group and zhulinduotang plus hepatitis B vaccine group, by double blind multicentres study. Results The improvement of subjective symptoms and recovery of liver function tests of the first group were much better than the second and the third group. And the sero-conversion of HBsAg, HBeAg and HBVDNA of the first group were 4.3%,53.0% and 53.3%m respectively, and those in the second and third group. No side-effect was observed during the treatment and during follow-up. Hence, PSTF can be considered as an effective immuno-regulator for chronic hepatitis B.
出处
《肝脏》
1999年第3期157-159,共3页
Chinese Hepatology
关键词
慢性
乙型肝炎
免疫疗法
PSTF
Anti-hepatitis B placenta transfer factor Chronic hepatitis B Multi-centre study