摘要
基于超声提取-固相萃取(MW-SPE)预处理方法和高效液相色谱-串联质谱(HPLC-MS/MS)分析技术,对广州市超市蔬菜中4种喹诺酮类抗生素(QNs)的污染状况进行探查与健康风险评价.结果表明,4种喹诺酮类化合物的检出率均大于90%,蔬菜(干重,下同)中单个化合物最高含量约150μg/kg,总含量(ΣQNs)在10.16～193.25μg/kg之间,平均为74.38μg/kg,其中瓜果类(91.29μg/kg)>根茎类(82.09μg/kg)>叶菜类(52.30μg/kg),绿色蔬菜(104.49μg/kg)>无公害蔬菜(79.06μg/kg)>有机蔬菜(62.38μg/kg)>普通蔬菜(61.23μg/kg).食用蔬菜而摄入CIP+ENR的平均值和最高值分别为1.8μg和3.7μg,低于食用肉类而摄入CIP+ENR的最高限值(10μg).可见,蔬菜中普遍检出喹诺酮类抗生素,虽然其含量和健康风险相对较低,但其长期摄入与协同作用的潜在健康风险不容忽视.
Quinolones（QNs） including norfloxacin（NOR）,enrofolxacin（ENR）,ciprofloxacin（CIP） and lomefloxacin（LOM） in vegetables sampled from supermarkets of Guangzhou were determined using solid phase extraction and liquid chromatography-tandem mass spectrometry.The detected frequencies of four quinolone compounds in vegetables were all above 90%.The maximum concentration of individual compounds was about 150 μg/kg.Total concentrations of quinolones（∑QNs） ranged from 10.16 to 193.25 μg/kg（D.W.）,with the average of 74.38 μg/kg and the orders for different kinds of vegetables as followed：melon-fruit vegetable（91.29 μg/kg） rhizome vegetable（82.09 μg/kg）leafy vegetable（52.30 μg/kg）,and green vegetable（104.49 μg/kg）pollution-free vegetable（79.06 μg/kg）organic vegetable（62.38 μg/kg）routinely cultivated vegetable（61.23 μg/kg）.The average intake and the maximum intake of CIP＋ENR for human body via vegetable consumption were 1.8 μg and 3.7 μg respectively,which were lower than those with the maximum intake limit（10 μg） via meat consumption.So it can be concluded that quinolone antibiotics in vegetables were frequently detected.Though their concentrations and health risks to human body were relatively lower,potential health risk should not be neglected for long term intake and synergism of various antibiotics.
出处
《环境科学》
EI
CAS
CSCD
北大核心
2011年第6期1703-1709,共7页
Environmental Science
基金
国家自然科学基金项目(30671208
40773062)
中央高校基本科研业务费专项(21610410
21609709)
广东省自然科学基金重点项目(07117909)
广东省科技计划项目(2005B20801002
2006B20601003
2010B020311006)
广东省高校高层次人才项目
东莞市科技研究计划项目(2007108101110)
惠州市科技研究计划项目(2009B010001009)
