摘要
目的研究血清抗环瓜氨酸肽(CCP)抗体与类风湿关节炎(RA)临床指标的相关性并探讨抗CCP抗体在RA中的临床意义。方法检测218例RA,103例其他风湿性疾病,30例健康人中的抗CCP抗体的分布。比较抗CCP抗体与类风湿因子(RF)、CRP、ESR、PLT的相关性和关节肿痛、关节功能分级及X线分期的相关性。结果 218例RA病人中,抗CCP抗体的阳性率为94.6%,其他风湿性疾病的阳性率为6.8%,健康人群阳性率为3.3%。抗CCP抗体对RA的敏感性和特异性分别为94.6%和96.3%。与非RA组比较差异有统计学意义(P<0.05),RA组患者外周血抗CCP抗体水平与PLT、CRP呈正相关,与RF水平不具有相关性;与ESR呈弱相关(r=0.354,P=0.012)。与患者关节疼痛、肿胀具有相关性,而与关节压痛、功能分级、X线分期均无正性相关。结论抗CCP抗体对RA具有较高的诊断价值,抗CCP抗体水平与PLT、CRP呈正相关,与患者关节疼痛、肿胀具有相关性;与RF水平、关节压痛、功能分级、X线分期均无正性相关。
【Objective】 To explore the correlation between anti-cyclic citrullinated peptide（CCP） anti-body（anti-CCP） and clinical significance in patients with rheumatoid arthritis（RA）.【Methods】 Anti-CCP was detected by ELISA and the RF was tested by the rate scatting immunity method in 218 RA patients,103 other rheumatoid diseases patients and 30 normal controls.To compare the correlation among the anti-CCP and RF,CRP,ESR,PLT and other.【Results】 two hundred and seven（94.6%） RA sera,7（6.8%） other rheumatic disease sera and 1（3.3%） normal controls were found to be anti-CCP positive.The sensitivity of anti-CCP was 94.6% with high specificity（96.3%） in RA.Anti-CCP levels in serum correlated significantly with PLT,CRP,The degree of joint swelling in RA.Anti-CCP levels in serum was weakly correlated with ESR in RA.Anti-CCP levels in serum was negatively correlated with RF in RA.【Conclusions】 Anti-CCP presents a reasonable sensitivity（94.6%） with high specificity（96.3%） to RA and it is benefit to RA diagnosis.Anti-CCP reflects disease activity in certain extent.Anti-CCP is associated with PLT,CRP,ESR and joint swelling in RA.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2011年第13期1480-1482,共3页
China Journal of Modern Medicine
关键词
抗环瓜氨酸肽抗体
关节炎
类风湿
arthritis
rheumatoid
anti-cyclic citrullinated peptide antibody
