摘要
【目的】回顾性观察并比较绝经后骨质疏松几种常用治疗方法的疗效。【方法】282例绝经后骨质疏松患者分为3组:A组,给予骨化三醇胶丸0.25μg和钙尔奇D3600mg,均每日1次;B组,在骨化三醇和钙尔奇D3的基础上给予鲑鱼降钙素50U隔日1次至疼痛缓解,改为每周1次;C组,在骨化三醇和钙尔奇D3的基础上给予伊班膦酸钠3mg静脉滴注,每3个月1次。随访时间1年。分别在基线和12个月后记录骨密度,SF-36量表评价的生活质量和VAS疼痛评分。【结果】A组患者在骨密度、生活质量和疼痛评分均略有好转,但与基线比较未达显著性差异;B组患者在骨密度、生活质量和疼痛评分均有较大改善,与基线比有显著性差异;C组患者在上述指标均有明显改善,与基线比有显著性差异,且临床用药方法简单,依从性强。【结论】治疗绝经后骨质疏松,需联合用药,单纯补充钙剂和活性维生素D3不能有效提高骨密度;鲑鱼降钙素止痛迅速,能在一定程度改善骨密度和生活质量;伊班膦酸钠能提高骨密度、改善生活质量,且依从性好。
[Objective]To explore the efficacy of different therapies on post-menopause osteoporosis retrospectively.[Methods]A total of 282 cases of post-menopause patients with osteoporosis were enrolled and 3 different therapies were found：A） caltrate ＋ Vit D3;B） caltrate ＋ Vit D3 ＋ calcitonin;C） caltrate ＋ Vit D3 ＋ ibandronate.All patients were followed up for 1 year.BMD,quality of life based on SF-36,and VAS at baseline and 12th month were documented.[Results] Patients in group A improved in all the indexes above,though no significance was found in the assessment.Patients in group B improved significantly in BMD,quality of life and VAS when compared to baseline.Patients in group C improved significantly in all the indexes,and had better patient compliance.[Conclusion] Post-menopause osteoporosis should be treated with combined therapy.Calcitonin would provide rapid pain relieve.Ibandronate had better efficacy in BMD improvement,quality of life and VAS than calcitonin.
出处
《中山大学学报（医学科学版）》
CAS
CSCD
北大核心
2011年第3期379-382,共4页
Journal of Sun Yat-Sen University:Medical Sciences
关键词
绝经后骨质疏松
骨密度
伊班膦酸
鲑鱼降钙素
生活质量
osteoporosis
postmenopausal
bone mineral density
ibandronic acid
calcitonin
quality of life
