摘要
以“精原细胞”法为筛选模型，从云南土壤的一株链霉菌１７２５０的菌丝和发酵液中分离得到２个抗肿瘤抗生素１７２５０－Ｚ１和１７２５０－Ｚ２。经对其理化性质和光谱数据的分析，确证１７２５０－Ｚ１为醌霉素Ｃ，１７２５０－Ｚ２为醌霉素Ａ，并对醌霉素Ａ。
Two antibiotics 17250 Z 1 and 17250 Z 2 which had the strong positive activity of antispermatogonium were isolated from the fermentation broth of Streptomyces sp. 17250, which was isolated in a soil sample of Yunnan province, south west of China. Based on the UV, IR, FAB MS, 1 H NMR, 13 C NMR, DEPT, 1 H 1 H COSY and 1 H 13 C COSY spectra, their structures were determined. They are identified with quinomycin C and quinomycin A respectively. In this paper, the chemical shifts of 1 H NMR and 13 C NMR spectra of the two compounds were assigned and some error assignments of the 1H NMR, 13 C NMR spectra in other paper were corrected. Their bioactivities against bacteria and antispermatogonium had also been studied.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1999年第4期258-261,共4页
Chinese Journal of Antibiotics
