摘要
目的:比较伴和不伴鼻息肉的慢性鼻-鼻窦炎患者及正常对照患者前筛黏膜标本的细菌学特征。方法:在鼻内镜手术中获取前筛黏膜标本,进行需氧和厌氧培养。结果:送检前筛黏膜标本119例,经需氧和厌氧组织匀浆半定量细菌培养,104例标本细菌培养为阳性(细菌培养总阳性率为87.4%);其中慢性鼻-鼻窦炎不伴鼻息肉组(CRSNP-组)、慢性鼻-鼻窦炎伴鼻息肉组(CRSNP+组)、正常对照组需氧或兼性厌氧细菌培养阳性率分别为86.5%、85.7%、90.0%,3组比较差异无统计学意义(P>0.05)。3组患者的黏膜标本以需氧菌和厌氧菌混合感染为主,混合感染率分别为CRSNP-组78.4%、CRSNP+组81.0%、对照组85.0%,差异无统计学意义(P>0.05)。3组最常见需氧菌株为凝固酶阴性葡萄球菌、棒状杆菌属细菌,比较差异均无统计学意义(均P>0.05)。厌氧菌培养阳性率3组分别为78.4%、76.2%、77.5%,差异无统计学意义(P>0.05);最常见厌氧菌株为丙酸杆菌属细菌、消化链球菌属细菌,差异均无统计学意义(均P>0.05)。结论:CRSNP-组和CRSNP+组及对照组患者前筛黏膜标本的细菌学特征无明显差异,细菌感染并非是慢性鼻-鼻窦炎发生鼻息肉这一机制中的惟一因素。
Objective：To compare the bacteriologic features of anterior ethmoidal biopsy specimens between chronic rhinosinusitis without nasal polyps（CRSNP-）,chronic rhinosinusitis with nasal polyps（CRSNP＋） and control patients.Method：The biopsy specimens obtained during the nasal endoscopic surgery were cultured for aerobic and anaerobic bacteria.Result：One hundred and nineteen biopsy specimens were processed for homogenination and semiquantitatively bacterial culture of aerobe and anaerobe.Bacterial culture were positive in 104 specimens（total culture-positive rate was 87.4%）.The positive rate of aerobe or facultative anaerobe culture were 86.5%、85.7%、90.0% in CRSNP-group,CRSNP＋ group and control group,respectively.There were no significant differences between 3 groups（P〉0.05）.Mixed growth of aerobe and anaerobe bacteria were mainly detected in the biopsy specimens and the positive rate were 78.4%,81.0% and 85.0% in CRSNP-group,CRSNP＋ group and control group.There were no significant differences in 3 groups（P〉0.05）.The most common aerobe bacteria found in 3 groups were coagulase-negative staphylococci and corynebacterium species and there were no significant differences between 3 groups（〉P0.05）.The positive rate of anaerobic bacteria culture were 78.4%,76.2% and 77.5% in 3 groups.There were no significant differences between the groups（P〉0.05）.Propionibacterium and peptostreptococcus species were the most common anaerobes,and there were no significant differences between 3 groups（P〉0.05）.Conclusion：There are no significant differences in the bacteriologic features of ethmoidal biopsy specimens between CRSNP＋,CRSNP-and control patients.Therefore,bacterial infection may not play a key role in the pathogenesis of nasal polyps in CRS patients.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2011年第11期482-485,共4页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
关键词
慢性鼻-鼻窦炎
鼻息肉
细菌学
细菌培养
chronic rhinosinusitis
nasal polyps
bacteriology
bacterial culture
