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B型利钠肽动态变化对老年心衰患者心脏事件的预测价值 被引量:3

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摘要 目的评价动态多点血浆B型利钠肽(BNP)水平对老年慢性充血性心力衰竭(CHF)患者预后的预测价值。方法顺序前瞻性选择选取94例心功能Ⅲ~Ⅳ级(NYHA分级)老年CHF住院患者,测定入院时血浆BNP水平(BNP1)、出院时BNP水平(BNP2)及出院后2 w门诊随访时测定BNP水平(BNP3),超声检测左室舒张末内径(LVEDD)和左室射血分数(LVEF),并随访。主要观察终点为心源性死亡和心衰恶化再入院。统计学分析采用双变量相关分析、多元逐步回归及COX回归分析。结果引入变量:年龄、LVEDD、LVEF、BNP1、BNP2、BNP3,双变量相关分析与多元逐步回归分析显示,仅BNP1与心源性死亡时间及心衰再入院时间独立相关,COX回归分析同样只有BNP1(偏回归系数=0.005;P=0.000)是心脏不良事件的独立相关影响因素。结论对老年CHF患者BNP1可作为预测心衰预后的重要、可靠指标,是心脏不良事件的独立相关影响因素。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2011年第10期1764-1766,共3页 Chinese Journal of Gerontology
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参考文献12

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二级参考文献10

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