摘要
目的：探讨鼻咽癌（ＮＰＣ）凋亡相关基因Ｐ１６、ｂｃｌ－２及ｎｍ２３与ＮＰＣ的关系。方法：采用免疫组化Ｓ－Ｐ法对７３例ＮＰＣ、２０例无瘤ＮＰ组织的石蜡包埋标本中的Ｐ１６、ｂｃｌ－２及ｎｍ２３蛋白进行检测。结果：ＮＰＣ组织的Ｐ１６表达显著低于无瘤ＮＰ组织，而ｂｃｌ－２表达则显著高于无瘤ＮＰ组织（Ｐ＜０．０１）；Ｐ１６及ｂｃｌ－２蛋白表达与ＮＰＣ的临床分期相关（Ｐ＜０．０５）；ｎｍ２３与颈淋巴结转移相关。结论：ＮＰＣ细胞凋亡的抑制与ｂｃｌ－２蛋白过度表达及Ｐ１６基因的部分缺失有关。
Objective:To investigate the relationship between apoptosis gene and nasopharyngeal carcinoma(NPC) Methods:Expressions of p16,bcl-2 and nm23 protein were examined by immunohisytochemistory S-P stainning in 73 NPC tissues Results:P16 protein highly expressed in tumor free nasopharyngeal mucosa tissues,but bcl-2 protein in NPC tissues There was relationship between the expressions of p16 and bcl-2 protein and the stage of NPC Conclusion:Overexpression of bcl-2 and partial defection of p16 gene may explain the inhibition of celluar apoptosis in NPC
出处
《广西医科大学学报》
CAS
1999年第5期598-599,共2页
Journal of Guangxi Medical University
