摘要
目的:观察福莫司汀联合立体定向放射治疗治疗脑胶质瘤的临床疗效。方法:将手术证实的恶性胶质瘤35例随机分为对照组和治疗组。对照组给予立体定向放射治疗在术后3～5周开始进行,选用6MV-X线5～7个拉弧旋转等中心照射,80%剂量曲线包绕PTV为5.0GY/次,总量DT45GY/9次,共3周。治疗组在对照组的基础上加用福莫司汀(山东),按体表面积计算用药量。诱导期:每周100mg/m2,连续3周,然后休息5周,做有效评估,维持期治疗每3周静脉注射1次,共3～5次。放化疗前后作CT或MRI观察治疗效果。结果:治疗组疗效明显高于对照组,差异有统计学意义(P<0.05)。胃肠道反应和血象变化两组比较有统计学意义(P<0.05)。结论:脑胶质瘤术后采用福莫司汀联合立体定向放射治疗的疗效明显好于单纯立体定向放射治疗。
Objective：To observe the clinical efficacy of fotemustine combining stereotactic radiotherapy treatment for brain glioma. Methods： 35 Surgery confirmed patients of malignant glioma were randomly divided into the control group and the treatment group. The Control group： stereotactic radiation therapy started from 3 to 5 weeks after operation ,6MV X - ray ,5 - 7 non - coplanar radiation field centers. PTV dose of 80% per dose curve was 5.0GY, DT 45GY/9 times, with a total of three weeks. The treatment groups ： used fotemustine （Shandong） in basis of the control group, calculated doses ac-cording to body surface area. Induction period ： weekly 100mg/ma, for three weeks, and then five weeks rest and an effective assessment of the treatment period to maintain the intravenous injection every 3 weeks at a total of 3 to 5 times. Before and after radiotherapy and chemotherapy taked CT or MRI examination for treatment results. Results：Clinical observation： apparent high efficacy of the treatment group and the control group, the difference was statistical significance （P 〈 0. 05 ）. Side effects： gastrointestinal tract and blood as the changes in response to the two groups showed no statistical significance. Damage to liver function were statistically significant but could be restored in 8 weeks （45 - 56days ）. Conclusion ： The use in glioma after fotemustine combined stereotactic radiotherapy is significantly better than the efficacy of stereotactic radiotherapy alone.
