摘要
目的观察ZCOL-1、ZCOL-2、ZCOL-3对实验性胃溃疡的作用。方法采用小鼠无水乙醇和大鼠醋酸分别致胃溃疡模型,考察ZCOL-1对抗实验性胃溃疡的作用。结果 ZCOL-1、ZCOL-2、ZCOL-3均能使小鼠无水乙醇所致胃溃疡的溃疡面积明显减小(P<0.05)。在大鼠醋酸胃溃疡模型的实验中,ZCOL-1(50,100mg?kg-1)与蒸馏水组比较有明显差异(P<0.05)。结论 ZCOL-1对无水乙醇所致胃溃疡模型和大鼠乙酸型胃溃疡模型具有很好的预防和治疗效果。
Objective To study effects of the ZCOL-1,ZCOL-2 and ZCOL-3 on experimental gastric ulcer and get a medicine who showed the most conspicuous prophylactic effect.Methods In order to inspect the effects of ZCOL-1 on experimental gastric ulcer from the prophylactic effect and the therapeutic efficacy,we used the model caused by absolute alcohol in mice and the model caused by acetic acid in rats.Results ZCOL-1,ZCOL-2 and ZCOL-3 could reduce the areas of gastric ulcer caused by absolute alcohol in mice(P<0.05).ZCOL-1(50,100 mg?kg-1)showed obvious diferences from the group who was gived distilled water(P<0.05) on the model caused by acetic acid in rats.Conclusion ZCOL-1 showed obvious effects on the gastric ulcer caused by absolute alcohol and acetic acid.
出处
《中国中医药现代远程教育》
2011年第5期180-182,共3页
Chinese Medicine Modern Distance Education of China
