摘要
目的观察莫西沙星三联疗法治疗根治失败的幽门螺杆菌(Hp)感染的临床疗效及药物的不良反应。方法选取常规Hp根治失败的患者125例随机分成A、B两组,A组64例给予莫西沙星0.4g qd+泮托拉唑0.4g bid+阿莫西林1.0g bid;B组61例给予泮托拉唑0.4g bid+枸盐酸铋钾0.22g bid+呋喃唑酮0.2g bid+阿莫西林1.0g bid,A、B两组均服药1周。两组停服质子泵抑制剂及抗菌素4周后行^(14)C-BUT呼气试验检测Hp感染是否根治。结果 A、B两组的根治率分别为90.5%和75.4%(P<0.05);不良反应发生率分别为9.4%和22.8%(P<0.05)。A组比B组多支付医疗费用137.9元。结论莫西沙星三联疗法治疗根治失败的Hp感染是一种有效,安全的治疗方案。
Objective To investigate the efficacy and the associated symptoms of moxifioxacin-based readicate helicobacter pylori（Hp） after treatment failure.Methods 125 patients with initial treatment failure were randomly divided into 2 groups;group A（n = 64） took moxifloxacin 0.4 g qd ＋ pantoloc 0.4 g bid ＋ amoxillin 1.0 g bid;group B（n = 61 ） took pantoloc 0.4 g bid ＋ amoxiUin 1.0 g bid ＋ bismuth potassium citrate 0.22 g bid ＋ furazolidone 0.2 g bid.The patients in both groups were treated for one-week.Hp status was assessed four-weeks after the end of treatment by C-UBT breath test.Results The treatment was completed in all the 125 patients.The rates of Hp readication in goups A and B were 90.5%and 75.4%（P0.05）,The rates of the associated symptoms in groups A and B were 9.4%and 22.8%（P0.05）.The group A than group B was more 137.9 yuan for the medical fee.Conclusion The moxifloxacin-based triple therapies is an effective, safechoice after the eradication failure for Hp infection.
出处
《临床消化病杂志》
2011年第2期75-76,共2页
Chinese Journal of Clinical Gastroenterology
关键词
莫西沙星
幽门螺杆菌
根治失败
Moxifioxacin
Helicobacter pylori
Eradication failure
