摘要
背景与目的:放射治疗是鼻咽癌治疗的主要治疗手段,放射性脑病(Radiation Encephalopathy,REP)是最为严重的并发症之一,这种损伤往往是不可逆转的,极大地影响病人的生存质量和生存期。本文探讨鼻咽癌放疗后REP的临床特点。方法:回顾性分析1172例鼻咽癌放疗患者的临床资料,总结首程放疗后和再程放疗后REP患者的临床特点。结果:鼻咽癌再程放疗患者REP发生率(16.8%)明显高于首程放疗者(1.5%,P<0.05);再程放疗后REP中位潜伏期(19个月)明显短于首程放疗后REP中位潜伏期(50个月,P<0.05)。再程放疗剂量<56Gy脑损伤发生率3.0%,56～66Gy发生率6.4%,>66Gy发生率8.4%(P<0.05)。结论:鼻咽癌放疗后REP发生率与放疗程数,放疗剂量有明显相关性。
BACKGROUND OBJECTIVE： Radiotherapy is a major treatment modality for nasopharyngeal carcinoma（NPC）.Radiation encephalopathy（REP） is one of most severe complications of radiotherapy.The injury is always irreversible,it has a negative impact on the quality of life and survival of NPC patients.Our purpose is to study the clinical characteristics of patients with REP after radiotherapy in NPC patients.METHODS： The clinical data of 1172 patients with NPC were retrospectively analyzed,and the clinical features of REP after single-course radiotherapy and repeated radiotherapy were summarized.RESULTS： The incidence of REP in repeated radiotherapy group（16.8%） was higher than that in single-course radiotherapy group（1.5%,P〈0.05）.The median latency period of REP was shorter in repeated radiotherapy group（19 months） than that in single-course radiotherapy group（50 months,P〈0.05）.The incidence of REP was 3.0% in repeatedly irradiated patients with a dose 〈56 Gy group,6.4% with a dose 56～66 Gy,and 8.4% with radiation dose〉66 Gy（P〈0.05.CONCLUSION： The incidence of REP after radiotherapy in NPC patients has significant correlation with the course of radiotherapy and radiation doses.
出处
《中国神经肿瘤杂志》
2011年第1期43-45,共3页
Chinese Journal of Neuro-Oncology
关键词
鼻咽癌
放射治疗
放射性脑损伤
Nasopharyngeal carcinoma
Radiotherapy
Radiation encephalopathy
