摘要
胃癌是常见的消化系恶性肿瘤,传统的化疗和放疗效果均不甚理想.表皮生长因子受体(epidermal growth factor receptor,EGFR)信号转导通路在胃癌细胞的增殖、血管生成、侵袭、转移等方面有重要作用.因此,针对EGFR的靶向药物已陆续开发并将逐步应于胃癌治疗的临床实践.本文就EGFR抑制剂在胃癌中的作用及相关问题作一综述.
Gastric cancer is one of the most common digestive system malignancies.Traditional chemoradiotherapy has modest efficacy in the treatment of gastric cancer.The epidermal growth factor receptor（EGFR）signal transduction pathway plays an important role in tumor proliferation,angiogenesis,invasion,and migration.EGFR inhibitors have been and are being developed to treat gastric carcinoma.In this paper,we review the role of EGFR inhibitors in the treatment of gastric carcinoma.
出处
《世界华人消化杂志》
CAS
北大核心
2011年第11期1150-1155,共6页
World Chinese Journal of Digestology
关键词
胃癌
表皮生长因子受体抑制剂
耐药性
检测方法
Gastric cancer
Epidermal growth factor receptor inhibitors
Drug resistance
Test methods
