摘要
目的观察涪陵地区食盐碘化后甲状腺功能亢进症(甲亢)病例就诊变化趋势和临床特点,分析影响因素。方法收集2000-2009年涪陵地区涪陵中心医院门诊甲亢病例资料;以T3(FT3)或T4(FT4)升高、TSH降低,结合病人甲亢临床表现诊断为甲亢;计算甲亢年发现率;用F检验分析甲状腺容积和肿大变化趋势,χ2检验分析甲亢年发现率变化。结果共发现甲亢病例1995例,年均病例发现率为17.78/10万,其中,2000-2003年发现率为14.55/10万,2004-2009年发现率为19.85/10万,后阶段显著高于前阶段(χ2=42.83,P<0.01)。患者甲状腺容积平均为46.15ml,肿大率为79.80%,甲状腺容积和肿大率均呈下降趋势(F=22.13、62.84,P<0.01)。30岁起,随着年龄的增长,甲状腺容积和甲状腺肿大率均呈下降趋势(F=31.02、117.50,P<0.01/0.05);病例女性多于男性(1∶2.5),发病主要年龄集中在20～50岁组(占92.94%)。结论涪陵区2000-2009年甲亢发现率呈上升趋势,甲亢患者甲状腺容积和甲状腺肿大率呈下降趋势,可能与全民食盐加碘有关。
Objective To observe the trend and clinical features of hyperthyroidism before and after using iodised salt in the district of Fuling,and analyze the influence factors.Methods Data on hyperthyroidism cases was collected from the central hospital of Fuling from 2000-2009.Based on the elevating of T3（FT3） or T4（FT4） and reducing of TSH together with the clinical conformation of hyperthyroidism symptoms,the trend of the change of thyroid volume and the change of morbidity rate of hyperthyroidism were analyzed with F test and χ2 test,respectively.Results Totally,1995 patients with hyperthyroidism were diagnosed.The overall average annual morbidity rate was 17.78/100000,and the average annual morbidity rate from 2000-2003 was 14.55/100000,but it was 19.85/100000 from 2004 to 2009,with an obviously increase （χ2 is 42.83,and P 0.01）.The average thyroid volume of all patients was 46.15 milliliter and incidence rate of goiter was 70.80%.Both of them have the trend of decrease （the value of F were 22.13 and 62.84,respectively,P0.01）.Above 30 years old,the thyroid volume and the incidence rate of goiter also have the trend of decrease with the increase of age （the value of F were 31.02 and 117.50,respectively,P0.01/0.05）.To all patients,the morbidity rate of female is higher than that of male （the proportion of female to male is 2.5∶1）,and the ages of most patients were in the group of 20 to 50 years old （occupy 92.94%）.Conclusion The morbidity rate of hyperthyroidism was increased,and conversely,the thyroid volume and the incidence rate of goiter were decreased in the district of Fuling from 2000 to 2009,all these may be as a result of using iodised salt.
出处
《热带医学杂志》
CAS
2011年第4期444-446,共3页
Journal of Tropical Medicine
基金
重庆市科技攻关计划项目(CSTC
2008AB5054)
