摘要
背景:幽门螺杆菌(H.pylori)一线三联疗法的根除失败率日益增高。目的:评价含多西环素的四联方案补救治疗H.pylori初次根除失败的有效性和安全性。方法:共纳入37例H.pylori初次根除失败的消化性溃疡、慢性萎缩性胃炎或非溃疡性消化不良患者,予四联方案埃索美拉唑(20 mg)+枸橼酸铋钾(220 mg)+多西环素(100 mg)+阿莫西林(1000 mg),2次/d×10 d。治疗结束4周后行13C-尿素呼气试验(UBT)以评估H.pylori根除情况。结果:4例患者失访,25例患者补救治疗成功,8例失败,补救治疗意向治疗(ITT)分析和符合方案(PP)分析根除率分别为67.6%和75.8%。21例(63.6%)患者发生轻微不良反应。结论:含多西环素的四联方案是一种安全、有效的H.pylori初次根除失败后的补救治疗方案。
The failure rate of first-line triple therapy for Helicobacter pylori （H. pylori） is increasing in recent years. Aims： To assess the efficacy and safety of doxycycline-based quadruple regimen as a rescue therapy after failure of initial eradication therapy of H. pylori. Methods： Thirty-seven patients with peptic ulcer, chronic atrophic gastritis or non-ulcer dyspepsia, who had a failed course of initial eradication therapy, were given the following quadruple therapy： esonaeprazole （20 nag）＋bismuth potassium citrate （220 nag）＋doxycycline （100 mg）＋anaoxicillin （1000 nag）, twice daily for l0 days. The status of H. pylori was assessed by 13C-urea breath test （UBT） 4 weeks after therapy. Results： Four patients dropped out in the follow-up study, 25 patients had their H. pylori successfully eradicated, and 8 patients remained H. pylori positive. The H. pylori eradication rates of rescue therapy by intention-to-treat （ITT） and per-protocol （PP） analysis were 67.6% and 75.8%, respectively. Slight or mild side effects occurred in 21 （63.6%） patients. Conclusions： Doxycycline-based quadruple regimen is a safe and effective rescue therapy after a failed initial eradication therapy.
出处
《胃肠病学》
2011年第4期211-213,共3页
Chinese Journal of Gastroenterology
关键词
多西环素
螺杆菌
幽门
药物疗法
治疗
临床研究性
Doxycycline
Helicobacter pylori
Drug Therapy
Therapies, Investigational
