摘要
应用小鼠碳粒廓清实验方法研究了铅、镉、铬和锰对单核-巨噬细胞系统(M-PS)吞噬功能的影响。结果显示,小鼠分别连续接触硝酸铅(96mg/kg)、硫酸镉(7mg/kg)和重铬酸钾(5mg/kg)5天后,血中胶体碳粒的廓清速率比对照组明显降低。说明铅、镉和铬对MPS的整体吞噬功能具有免疫毒性作用。
Using the technique for measuring clearance rate of intravascular celleidal carbon, we studied the effects of lead, cadmium, chromate and manganese on the phagocytic function of mononuclear phagocytic system ( MPS ) in normal ICR strain mice.The results showed that in mice exposed to lead nitrate ( 96mg/kg ) , cadmium sulfat; ( 7mg/ kg ) , potassium bichromate ( 5mg/kg ) for 5 days, the clearance rata of intravascular colloidal carbon was decreased significantly as compared with control group. It suggested that Pb. Cd and Cr may inhibit the phagocytic activity of MPS.
出处
《卫生毒理学杂志》
CSCD
1990年第2期95-97,共3页
Journal of Health Toxicology
关键词
吞噬作用
巨噬细胞
铅
镉
铬
锰
Clearance rats of charcoal particles
Phagocytosis
MPS
Heavy metal.
