摘要
以17β-雌二醇为阳性对照组,观察不同浓度淫羊藿次甙Ⅱ对成骨细胞护骨素（OPG）表达的影响,结果发现20.ng/dl淫羊藿次甙Ⅱ上调成骨细胞OPGmRNA的表达,且优于阳性对照组（P〈0.05）,淫羊藿次甙Ⅱ也显著增加成骨细胞OPG分泌水平,20 ng/dl淫羊藿次甙Ⅱ组的促分泌活性显著优于阳性对照组,提示淫羊藿次甙Ⅱ作为淫羊藿甙在体内的主要代谢产物,在体外较低剂量即可显著促进成骨细胞OPG的表达,具有良好的抗骨质疏松作用.
To explore the effect of icariside ？ on osteoprotegerin（OPG） expression in osteoblasts, primary osteoblasts were cultured with different concentration of icariside ？ and 17？estradiol. As a major metabolite of icarrin in vivo, icariside ？ exerted a better effect on OPG expression which plays a key role in osteoporosis. 20 ng/dl icariside ？ also exerted better effect on OPG secretion than that of positive control group. Consequently, icariside ？could be a candidate for osteoporosis treatment.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2011年第4期337-338,共2页
Chinese Journal of Endocrinology and Metabolism
基金
国家自然科学基金资助项目（30840106）
