摘要
目的测定新藤黄酸固体脂质纳米粒(solid lipid nanoparticles,SLN)在大鼠血浆中的稳定性。方法采用高效液相色谱法,通过测定对比新藤黄酸对照品溶液和新藤黄酸SLN在大鼠血浆中的渗漏率,考察新藤黄酸SLN在血浆中的稳定性。结果新藤黄酸对照品溶液的渗漏率为71.2%,新藤黄酸SLN的渗漏率为38.5%。结论表明新藤黄酸SLN相对于对照品溶液,在血浆中稳定。
Aim To detect the stability of solid lipid nanoparticle in rat plasma.Methods Through detecting and contrasting the leakage rate of neo-gambogic acid reference solution and neo-gambogic acid SLN by HPLC,the stability of neo-gambogic acid SLN in rat plasma was examined.Results The leakage rate of neo-gambogic acid reference solution was 71.2%,and the neo-gambogic acid SLN was 38.5%.Conclusion Neo-gambogic acid SLN has higher stability than neo-gambogic reference solution.
出处
《安徽医药》
CAS
2011年第6期679-680,共2页
Anhui Medical and Pharmaceutical Journal
基金
安徽省教育厅重点项目(NoKJ2011A190)
关键词
新藤黄酸
固体脂质纳米粒
渗漏率
稳定性
neo-gambogic acid
solid lipid nanoparticles
leakage rat
stability
