期刊文献+

高频电刺激对神经动作电位阻断作用的研究 被引量:2

Blocking effect of high frequency alternating current signal to nerve action potential conduction
下载PDF
导出
摘要 目的:研究了高频交流电信号对神经动作电位的阻断作用。方法:采用离体的蟾蜍坐骨神经进行实验,对神经施加高频的正弦信号,观察动作电位的幅度和肌肉的状态来确定阻断的效果。结果:在一定频率下,高频正弦信号能完全阻断神经传导,阻断的阈值随阻断信号频率的增加而增加。给肌肉一小段时间高于阻断信号频率的刺激,肌肉对高频信号的强直效应会消失,之后肌肉的收缩也能被高频信号阻断。结论:高频电刺激对神经动作电位阻断作用为临床局麻、镇痛和解痉探索提供了新的依据。 Objective:To investigated the blocking effect of high frequency alternating current signal to nerve action potential conduction. Methods:Frog sciatic nerve was dissected out in the experiments. The amplitude of action potential(AP) and the state of muscle during high-frequency sinusoidal stimulation were observed to determine the blocking effect. Results:The results showed that in a certain frequency complete block could be achieved at the threshold. When the stimulation amphtude increased upon threshold, there was no obvious difference in the character of the block. With an increase in frequency, block threshold also increased. The muscle tetanus due to the block frequency stimulation vanished after a short period signals whose frequency was higher than the block frequency were induced. In the following course, the muscle contraction was blocked by high frequency AC signal. Conclusion: Blocking effect of high frequency AC signal to nerve action potential conduction can potentially provide new methods for clinical applications of electrical nerve block in local anesthesia, acesodyne and spasmolysis.
出处 《南京医科大学学报(自然科学版)》 CAS CSCD 北大核心 2011年第5期706-710,776,共6页 Journal of Nanjing Medical University(Natural Sciences)
基金 国家自然科学基金(30670767) 东南大学生物电子学国家重点实验室开放研究基金资助
关键词 高频电刺激 正弦信号刺激 神经阻断 阻断阈值 肌肉张力 high frequency electrical stimulation sine wave stimulation nerve block block threshold muscle tension
  • 相关文献

参考文献17

  • 1孙凤艳..医学神经生物学[M].上海:上海科学技术出版社,2008:385.
  • 2Niloy Bhadra, KilgoreKL. Direct current electrical conduction block of peripheral nerve [J]. IEEE Trans on Neural Systems and Rehabilitation Eng,2004,12 (3): 313-324. 被引量:1
  • 3Kilgore KL, Bhadra N. Nerve conduction block utilislng high frequency alternating current[J].Med Biol Eng C omput, 2004,42 (3) : 394-406. 被引量:1
  • 4李天钢,马春排著..生物医学测量与仪器 原理与设计[M].西安:西安交通大学出版社,2009:321.
  • 5Niloy Bhadra, Emily A Lahowetz. Simulation of high-frequency sinusoidal electrical block of mammalian myelinated axons [ J ], J Comput Neurosci, 2007,22 (3) : 313- 326. 被引量:1
  • 6Niloy Bhadra,Kilgore KL. High-Frequency electrical conduction block of mammalian peripheral motor nerve [J]. Muscle Nerve, 2005,32(6) : 782-790. 被引量:1
  • 7Narendra B, Niloy B. High frequency electrical conduction block of the pudendal nerve [J]. Journal of Neural Engineering, 2006,3 (2) : 180-187. 被引量:1
  • 8Kevin LK,Niloy B. High frequency mammalian nerve conduction block:simulations and experiments [J]. Proceedings of the 28th IEEE EMBS Annual International Conference, 2006,1 : 4971-4974. 被引量:1
  • 9Alicia LJ, Dominique MD. High frequency stimulation can block axonal conduction [J]. Experimental Neurology, 2009,220(1) : 57-70. 被引量:1
  • 10Ackermamn DM, Emily L Effect of bipolar cuff electrode design on block thresholds in high-frequency electrical neural conduction block [J]. IEEE Trans on Neural Systems and Rehabilitation Eng,2009, 17(5) :469-477. 被引量:1

二级参考文献47

  • 1高兴亚,王汉军,朱国庆,郭瑞,张枫,张颖,陆祖宏.Effect of Implanted Chip System on Blood Pressure Regulation in Rabbits[J].Journal of Nanjing Medical University,2004,8(6):279-282. 被引量:1
  • 2张旭,邰常峰,马斌荣.用高频双向脉冲电刺激实现有髓神经传导阻断的仿真研究[J].北京生物医学工程,2006,25(3):280-284. 被引量:8
  • 3Tai C,Roppolo JR and de Groat WC.Block of external urethral sphincter contraction by high frequency electrical stimulation of pudendal nerve.J Urol,2004,172:2069-2072 被引量:1
  • 4Baratta R,Ichie M,Hwang SK,et al.Orderly stimulation of skeletal muscle motor units with tripolar nerve cuff electrode.IEEE Trans Biomedical Engineering,1989,36:836-843 被引量:1
  • 5Fang ZP,Mortimer JT.A method to effect physiological recruitment order in electrically activated muscle.IEEE Trans Biomedical Engineering,1991,38:175-179 被引量:1
  • 6Tai C and Jiang D.Selective stimulation of smaller fibers in a compound nerve trunk with single cathode by rectangular current pulses.IEEE Trans Biomedical Engineering,1994,41:286-291 被引量:1
  • 7Agnew WF.and McCreery DH.Neural Prostheses:Fundamental Studies.Prentice Hall,Englewood Cliffs,NJ.1990 被引量:1
  • 8Kilgore KL,Bhadra N.Nerve conduction block utilising highfrequency alternating current.Medical Biological Engineering Comput,2004,42:394-406 被引量:1
  • 9Reboul J and Rosenblueth A.The action of alternating currents upon the electrical excitability of nerve.Am J Physiol,1939,125:205-215 被引量:1
  • 10Rosenblueth A and Reboul J.The blocking and deblocking effects of alternating currents on nerve.Am J Physiol,1939,125:251 被引量:1

共引文献9

同被引文献11

引证文献2

二级引证文献6

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部