摘要
1例46岁女性,因银屑病关节炎自行服用苦丹丸2丸(6 g),3次/d。用药5 d后出现乏力、腹胀,继续服药症状加重,19d后停药。停药第2天患者皮肤、巩膜明显黄染,收入院。血生化检查:丙氨酸转氨酶1384 U/L,天冬氨酸转氨酶1311 U/L,总胆红素91.4μmol/L,直接胆红素53.5μmol/L,间接胆红素37.9μmol/L。诊断为药物性肝损害,给予甘草酸二铵、还原型谷胱甘肽等治疗。20 d后患者症状消失,肝功能基本恢复正常,遂出院。
A 46-year-old woman serf-medicated with 2 pills （6 g） of Kudan thrice daily for her psoriatic arthritis. After 5 days, the patient developed fatigue and abdominal distension. She continued taking the drug, and her symptoms worsened. Nineteen days later, Kudan pills were stopped. On day 2 after drug discontinuation, she had markedly jaundiced skin and sclera, and then she was hospitalized. Biochemical tests revealed the following values： ALT 1384 U/L, AST 1311 U/L, TBil 91.4 μmol/L, DBil 53.5 μmol/L, IBil 37.9 μmol/L. Drug-induced live damage was diagnosed and she received glycyrrhizin diammonium, reduced glutathione and other treatment. Twenty days later, her symptoms disappeared and liver function basically returned to normal, and then she was discharged.
出处
《药物不良反应杂志》
2011年第2期131-132,共2页
Adverse Drug Reactions Journal
关键词
苦丹丸
肝损害
Kudan pills
liver damage
