摘要
目的探讨护理干预对化疗周期中非霍奇金淋巴瘤（NHL）患者血小板活化标志物PAC-1和CD62p表达的影响。方法将30例NHL患者（观察组）随机等分为单纯化疗组（15例）和化疗联合护理干预组（15例），应用流式细胞术（FCM）检测化疗当天（d0）、第3天（d3）、第7天（d7）及第14天（d14）血小板PAC-1和CD62p的表达水平，并选择15例健康体检者作对照组。观察分析3组结果。结果病例组血小板PAC-1高于对照组，差异有统计学意义[（5．63±1．68）％比（3．43±1．07）％，t=5．323，P〈0．01]，CD62p高于对照组，差异有统计学意义[（4．17±1．79）％比（2．44±0．78）％，t=3．576，P〈0．01]；在单纯组和十预组，化疗d0，d3，d7，d14PAC-1CD62p的表达水平组内比较差异有统计学意义（P〈0．05或P〈0．01）；组间比较差异均无统计学意义（P〉0．05）。干预组化疗d7、d14的PAC-1和CD62p较单纯组呈现’卜降趋势，但差异无统计学意义（P〉0．05）。结论护理干预可能对化疗周期中非霍奇金淋巴瘤患者血小板活化有抑制作用。
Objective To research the influence of nursing intervention on platelet activation markers PAC-1 and CD62p during a chemotherapy cycle in non Hodgkin＇ s lymphoma （NHL） patients. Methods 30 NHL cases were randomly divided into two equal parts including simple chemotherapy group （simple group） and chemotherapy plus vein nursing intervention group （intervention group）, and 15 healthy subjects were selected as control group. PAC-1 and CD62p expressions were detected by flow cytometry （FCM） at dO, d3, d7 and d14 during a chemotherapy cycle respectively. Results The expressions of PAC-1 and CD62p in disease group were significantly higher than those in control group （5.63 ± 1.68% vs 3.43 ± 1.07% , t = 5. 323, P 〈 0.01 for PCA-1, and 4.17± 1.79% vs 2.44 ±0.78%, t =3.576, P〈0.01 for CD62p）. In simple group and intervention group, PAC-1 at dO and d3 were higher than that at d14 （ P 〈 0. 05 or 0.01 ）, and CD62p at d3 was higher than those at dO, d7 and d14 in a chemotherapy cycle （P 〈 0.05 or 0.01 ）. PAC-1 and CD62p at d7 and d14 in intervention group inclined to decrease compared with those in simple group, but no statistical significance was found （ P 〉 0. 05 ）. Conclusions Nursing intervention may restrain platelet activation efficiently in NHL patients during chemotherapy.
出处
《中华现代护理杂志》
2011年第13期1523-1525,共3页
Chinese Journal of Modern Nursing
关键词
非霍奇金淋巴瘤
血小板活化
流式细胞术
护理干预
Non-Hodgkin＇ s lymphoma
Platelet activation
Flow cytometry
Nursing intervention
