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Notch信号通路与高血压的关系 被引量:1

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摘要 原发性高血压(essential hypertension,EH)是最常见的心血管疾病之一,更是诱发脑中风、冠心病、心力衰竭等常见重大疾病的主要危险因素。目前认为高血压是多基因、多诱因相互作用的结果,特别是遗传因素、膳食、神经内分泌、炎症等多种机制在高血压的发生发展中起着十分重要的作用。炎症作为一种高血压发病机制近来备受关注。
出处 《中国动脉硬化杂志》 CAS CSCD 北大核心 2011年第3期288-288,共1页 Chinese Journal of Arteriosclerosis
基金 国家杰出青年基金(81025001)
关键词 高血压 NOTCH 炎症
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  • 1Aster JC. In Brief: Notch signalling in health and disease[J]. J Pathol,2014, 232(1):1-3. 被引量:1
  • 2Xiang YJ, Dai SM. Prevalence of rheumatic diseases and disability in China [J]. Rheumatal Int,2009,29(5) :481.90. 被引量:1
  • 3Guilherme L, Ramasawmy R, Kalil J. Rheumatic fever and rheumatic heart disease : genetics and pathogenesis [ J ]. Seand J Immunol,2007,66 : 199-207. 被引量:1
  • 4Guilherme L, Kalil .I. Rheumatic Hea Disease: Molecules Involved in Valve Tissue Inflammation Leading to the Autoimmune Process and Anti-S. pyogenes Vaccine [ J ]. Front hnmunol, 2013,4 : 352. 被引量:1
  • 5Guilherme L, Kalil J. Rheumatic fever and rheumatic heart disea,,e: cellular mechanisms leading autoimmune reactivity and disease [ J ]. J Clin hnmunol, 2010,30( 1 ) :17-23. 被引量:1
  • 6Wang Z, Banerjee S, Li Y, et al. Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappa B, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells [ J ]. Cancer Res, 2006,66:2778-2784. 被引量:1
  • 7Zhao L, Borikova AL, Ben-Yair R, et al. Notch signaling regulates cardiomyo- cyte proliferation during zebra fish heart regeneration [ J ]. Proc Natl Acad Sci, 2014,111 (4) : 1403-1408. 被引量:1
  • 8Wolf M, Basson CT. The molecular genetics of congenital heart disease : a re- view of recent developments[J], Curt Opin Cardiol,2010,25(3) :192. 被引量:1
  • 9Garside VC, Chang AC, Karsan A, et al. Co-ordinating Notch, BMP, and TGF- signaling during heart valve development[J]. Cell Mal Life Sei, 2013, 70(16) :2899-2917. 被引量:1
  • 10de la Pompa JL, Epstein JA. Coordinating tissue interactions: Notch signaling in cardiac development and disease [ J ]. Dev Cell,2012,22 (2) : 244 -254. 被引量:1

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